通过整合应激反应蛋白 GADD34 来协调神经元活动依赖性翻译。
Orchestrating neuronal activity-dependent translation via the integrated stress response protein GADD34.
机构信息
Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou 311121, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China.
Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou 311121, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China; Research Units for Emotion and Emotion disorders, Chinese Academy of Medical Sciences, Beijing 100000, China.
出版信息
Trends Neurosci. 2024 May;47(5):319-321. doi: 10.1016/j.tins.2024.03.008. Epub 2024 Apr 13.
In a recent study, Oliveira and colleagues revealed how growth arrest and DNA damage-inducible protein 34 (GADD34), an effector of the integrated stress response, initiates the translation of synaptic plasticity-related mRNAs following brain-derived neurotrophic factor (BDNF) stimulation. This work suggests that GADD34 may link transcriptional products with translation control upon neuronal activation, illuminating how protein synthesis is orchestrated in neuronal plasticity.
在最近的一项研究中，Oliveira 及其同事揭示了生长停滞和 DNA 损伤诱导蛋白 34（GADD34），即综合应激反应的效应物，如何在脑源性神经营养因子（BDNF）刺激后启动突触可塑性相关 mRNA 的翻译。这项工作表明，GADD34 可能在神经元激活时将转录产物与翻译控制联系起来，阐明了蛋白质合成在神经元可塑性中的协调方式。
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