Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.
Dermatology Hospital, Southern Medical University, Guangzhou, China.
Skin Pharmacol Physiol. 2024;37(1-3):1-18. doi: 10.1159/000538832. Epub 2024 Apr 12.
The skin, particularly the epidermis, is subjected to various external stresses, including ultraviolet (UV) irradiation. UV irradiation, mainly UVB at wavelength of 280-315 nm, can alter several epidermal functions, including cutaneous inflammation, epidermal hyperproliferation, DNA damage, disruption of epidermal permeability barrier and reduction in stratum corneum hydration levels. Because of the negative impacts of UVB irradiation on epidermal functions, great efforts have been made to develop regimens for the protection of alterations in epidermal function induced by UV irradiation.
While sunscreen can provide physical barrier to UV light, some natural ingredients can also effectively protect the skin from UVB irradiation-induced damages. Studies have demonstrated that either topical or oral administrations of some natural ingredients attenuate UVB irradiation-induced alterations in the epidermal function. The underlying mechanisms by which natural ingredients improve epidermal functions are attributable to antioxidation, stimulation of keratinocyte differentiation, increases in the content of epidermal natural moisturizers and inhibition of inflammation.
Some natural ingredients exhibit protective and therapeutical benefits in photo-induced epidermal dysfunctions via divergent mechanisms.
皮肤，尤其是表皮，会受到各种外部压力的影响，包括紫外线（UV）辐射。UV 辐射，主要是波长为 280-315nm 的 UVB，可以改变几种表皮功能，包括皮肤炎症、表皮过度增生、DNA 损伤、表皮通透性屏障破坏和角质层水分含量降低。由于 UVB 辐射对表皮功能的负面影响，人们已经做出了巨大的努力来开发保护方案，以防止 UV 辐射引起的表皮功能改变。
防晒霜可以为皮肤提供物理屏障，以阻挡紫外线，但一些天然成分也可以有效地保护皮肤免受 UVB 辐射引起的损伤。研究表明，一些天然成分的局部或口服给药可以减轻 UVB 辐射引起的表皮功能改变。天然成分改善表皮功能的潜在机制归因于抗氧化作用、刺激角质形成细胞分化、增加表皮天然保湿因子的含量和抑制炎症。
一些天然成分通过不同的机制在光诱导的表皮功能障碍中表现出保护和治疗作用。
