Kim Min Hye, Kim Kyeong Ah, Kim Jeong Woo, Lee Seok Young, Choi Jae Woong
J Korean Soc Radiol. 2024 Mar;85(2):437-444. doi: 10.3348/jksr.2023.0102. Epub 2024 Mar 26.
Concomitant renal cell carcinomas (RCC) of both native and allograft kidneys are extremely rare, and only a few cases have been reported in the available English literature. A particularly rare variant within the adult population is the Xp11.2 translocation/transcription factor E3 (TFE3)-rearranged RCC. Although few case reports of TFE3-rearranged RCC have been reported in children who underwent kidney transplantation (KT), no case of adults with TFE3-rearranged RCC following KT has been reported. Herein, we presented the radiological and pathological findings of a rare metachronous papillary RCC in the allograft kidney and TFE3-rearranged RCC in the native kidney. The TFE3-rearranged RCC in the native kidney exhibited slow expansion in size over five years. Radiologically, it appeared as a slightly enhanced, lobulated mass on contrast-enhanced CT. MRI revealed high signal intensity on T1-weighted images and low signal intensity on T2-weighted images.
同时发生于自体肾和移植肾的肾细胞癌（RCC）极为罕见，现有英文文献中仅报道了少数病例。在成年人群中，一种特别罕见的变异类型是Xp11.2易位/转录因子E3（TFE3）重排的RCC。尽管在接受肾移植（KT）的儿童中已有少数TFE3重排RCC的病例报告，但尚未有成人KT后发生TFE3重排RCC的病例报道。在此，我们展示了一例罕见的移植肾异时性乳头状RCC和自体肾TFE3重排RCC的影像学及病理表现。自体肾中TFE3重排的RCC在五年内大小呈缓慢增大。在影像学上，对比增强CT显示为稍强化的分叶状肿块。MRI显示在T1加权图像上为高信号强度，在T2加权图像上为低信号强度。
