School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Obes Surg. 2024 Jun;34(6):2066-2072. doi: 10.1007/s11695-024-07211-7. Epub 2024 Apr 15.
Obesity and ADHD have become increasingly common diagnoses. In the last decade, research has found that there is a high prevalence of obesity in patients with ADHD. The mainstays of management in the general population include lifestyle modifications, pharmacotherapies, and/or bariatric surgery. However, there is a lack of understanding of appropriate management of patients with both ADHD and obesity.
We identified those with obesity for at least five consecutive years (BMI > 30) in the TriNetX database before separating into two groups based on the presence or absence of ADHD. We assessed both the distribution of treatment modalities and the change in average BMI over time in each of our four groups across 5 years.
Average BMI decreased over time in all groups, with the smallest change seen in the ADHD Pharmacology cohort (- 0.366 kg/m) and the largest in the ADHD Surgery group (- 8.532 kg/m). Average BMIs at the 5-year mark were significantly different.
Our research found that pharmacological management of individuals with ADHD was only half as effective for individuals with ADHD than our control. Though surgical management of patients with ADHD is roughly 20 times more effective in managing obesity, it was not used as frequently in comparison to medication for management of weight.
肥胖症和注意力缺陷多动障碍(ADHD)的发病率越来越高。在过去的十年中,研究发现 ADHD 患者中肥胖症的发病率很高。一般人群的主要治疗方法包括生活方式改变、药物治疗和/或减肥手术。然而,对于同时患有 ADHD 和肥胖症的患者,其管理方法尚缺乏了解。
我们在 TriNetX 数据库中确定了至少连续 5 年存在肥胖症(BMI>30)的患者,然后根据是否存在 ADHD 将其分为两组。我们评估了在 5 年内,每组患者在治疗方式的分布和平均 BMI 随时间的变化。
所有组的平均 BMI 随时间逐渐下降,ADHD 药理学组的变化最小(-0.366kg/m),ADHD 手术组的变化最大(-8.532kg/m)。5 年后的平均 BMI 存在显著差异。
我们的研究发现,与对照组相比,ADHD 药物治疗对 ADHD 患者的效果只有一半。虽然 ADHD 患者的手术治疗在肥胖症管理方面的效果大约是药物治疗的 20 倍,但与药物治疗相比,手术治疗用于肥胖症管理的频率要低得多。