IEEE Trans Neural Syst Rehabil Eng. 2024;32:1657-1667. doi: 10.1109/TNSRE.2024.3389022. Epub 2024 Apr 25.
In certain neurological disorders such as stroke, the impairment of upper limb function significantly impacts daily life quality and necessitates enhanced neurological control. This poses a formidable challenge in the realm of rehabilitation due to its intricate nature. Moreover, the plasticity of muscle synergy proves advantageous in assessing the enhancement of motor function among stroke patients pre and post rehabilitation training intervention, owing to the modular control strategy of central nervous system. It also facilitates the investigation of long-term alterations in remodeling of muscle functional performance among patients undergoing clinical rehabilitation, aiming to establish correlations between changes in muscle synergies and stroke characteristics such as type, stage, and sites. In this study, a three-week rehabilitation monitoring experiment was conducted to assess the motor function of stroke patients at different stages of rehabilitation based on muscle synergy performance. Additionally, we aimed to investigate the correlation between clinical scale scores, rehabilitation stages, and synergy performance in order to provide a more comprehensive understanding of stroke patient recovery. The results of 7 healthy controls and 16 stroke patients showed that high-functioning patients were superior to low-functioning patients in terms of motor function plasticity towards healthy individuals. Moreover, there was a high positive correlation between muscle synergies and clinical scale scores in high-functioning patients, and the significance gradually emerged with treatment, highlighting the potential of muscle synergy plasticity as a valuable tool for monitoring rehabilitation progress. The potential of this study was also demonstrated for elucidating the physiological mechanisms underlying motor function reconstruction within the central nervous system, which is expected to promote the further application of muscle synergy in clinical assessment.
在某些神经疾病中，如中风，上肢功能的损伤会显著影响日常生活质量，需要增强神经控制。由于其复杂性，这在康复领域构成了巨大的挑战。此外，肌肉协同作用的可塑性在评估中风患者康复训练前后运动功能的增强方面具有优势，因为中枢神经系统采用了模块化控制策略。它还促进了对接受临床康复治疗的患者肌肉功能性能长期重塑变化的研究，旨在建立肌肉协同作用变化与中风特征（如类型、阶段和部位）之间的相关性。在这项研究中，进行了为期三周的康复监测实验，以根据肌肉协同作用表现评估不同康复阶段中风患者的运动功能。此外，我们旨在研究临床量表评分、康复阶段和协同作用表现之间的相关性，以便更全面地了解中风患者的恢复情况。7 名健康对照者和 16 名中风患者的结果表明，高功能患者在向健康个体的运动功能可塑性方面优于低功能患者。此外，高功能患者的肌肉协同作用与临床量表评分之间存在高度正相关，并且随着治疗的进行，相关性的显著性逐渐显现，突出了肌肉协同作用可塑性作为监测康复进展的有价值工具的潜力。这项研究的潜力还在于阐明中枢神经系统内运动功能重建的生理机制，这有望促进肌肉协同作用在临床评估中的进一步应用。
