Lee Jeongmin, Baek Han-Sang, Jo Kwanhoon, Kim Min-Hee, Lee Jung Min, Chang Sang Ah, Lim Dong-Jun
Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 03312, Republic of Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.
J Clin Endocrinol Metab. 2025 Feb 18;110(3):e717-e727. doi: 10.1210/clinem/dgae178.
Thyroid hormones are essential for energy metabolism related to thermogenesis and oxygen consumption.
This study evaluated the potential association of thyroid function including thyroid peroxidase antibodies (TPOAb) with physical activity in nationally representative data.
DESIGN/SETTING/PARTICIPANTS: This retrospective cohort study used data from the Korean National Health and Nutrition Examination Survey between 2013 and 2015. Physical activity (PA) was assessed using metabolic equivalents based on the validated Korean version of the International Physical Activity Questionnaire Short Form. PA level was categorized into 3 groups of high, moderate, and low. Participants with abnormal thyroid function test, restricted activity, or previous history of thyroid disease were excluded in the study.
A total of 5372 participants was finally selected. The free T4 level was lowest in the low PA group, while TSH was not significantly different among the groups. TPOAb titers increased in the following order: moderate PA, low PA, and high PA. After adjustment for confounding factors, moderate PA was associated with a high T4 level and a decrease in TSH and TPOAb with significance. However, there were no significant changes in free T4, TSH, or TPOAb titer in the high PA group. In a subanalysis, females with moderate PA showed a significant decrease in TSH and TPOAb. In both males and females, insulin sensitivity was increased with moderate PA. In obese participants, TSH negatively correlated with PA, and free T4 levels decreased in the low PA. The sensitivity to thyroid hormone did not differ in our study.
The present study found an association between thyroid function and moderate PA. Therefore, moderate-intensity PA should be recommended to improve thyroid function.
甲状腺激素对于与产热和耗氧相关的能量代谢至关重要。
本研究在具有全国代表性的数据中评估了包括甲状腺过氧化物酶抗体（TPOAb）在内的甲状腺功能与身体活动之间的潜在关联。
设计/地点/参与者：这项回顾性队列研究使用了2013年至2015年韩国国家健康与营养检查调查的数据。基于经过验证的韩国版国际身体活动问卷简表，使用代谢当量评估身体活动（PA）。PA水平分为高、中、低三组。研究排除了甲状腺功能测试异常、活动受限或有甲状腺疾病既往史的参与者。
最终共入选5372名参与者。低PA组的游离T4水平最低，而各组之间的促甲状腺激素（TSH）无显著差异。TPOAb滴度按以下顺序升高：中度PA、低度PA和高度PA。在调整混杂因素后，中度PA与高T4水平以及TSH和TPOAb的降低具有显著相关性。然而，高PA组的游离T4、TSH或TPOAb滴度没有显著变化。在亚组分析中，中度PA的女性TSH和TPOAb显著降低。在男性和女性中，中度PA均可提高胰岛素敏感性。在肥胖参与者中，TSH与PA呈负相关，低PA组的游离T4水平降低。在我们的研究中，甲状腺激素敏感性没有差异。
本研究发现甲状腺功能与中度PA之间存在关联。因此，应建议进行中等强度的PA以改善甲状腺功能。
