As the COVID-19 pandemic became a global health concern, many business activities have had to adjust to the protocols required to keep people safe, thereby altering the work structures of many professionals. With data gathered from 466 respondents in Nigeria, of which approximately 70% are from the South-West, this study shows how the factors associated with the health crisis have affected work productivity during this period. The snowball survey research design techniques with the two-way interaction model were employed. Multiple Correspondence Analysis was used to analyse and understand multiple and pairwise qualitative factors that influence productivity. The first part of the analysis identified boredom, remuneration, internet availability, fear of COVID-19 and depressing news of COVID-19 as the factors that had significant impacts on workers' productivity. The second part of the analysis shows how the categories of the five significant factors were either associated or not with productivity. An analysis of each of these factors showed that fear of the disease was associated with slight productivity but access to internet facilities and remuneration were strongly associated with improved work productivity, while boredom and depressing news about COVID-19 were associated with non-productivity during this period. Further evidence also showed that training and new skills acquisition might improve workers' productivity much more. We, therefore, recommend dynamic skills acquisition, training, and investment in tools and services that will enhance flexibility with the changing work structure that comes because of global crises.