新型冠状病毒感染后早期与延迟移植的临床结局比较。
Comparison of the Clinical Outcomes Between Early and Delayed Transplantation After SARS-CoV-2 Infection.
机构信息
Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Infectious Diseases, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
出版信息
J Korean Med Sci. 2024 Apr 15;39(14):e137. doi: 10.3346/jkms.2024.39.e137.
Our study analyzed 95 solid organ transplant (SOT) and 78 hematopoietic stem cell transplant (HSCT) recipients with prior coronavirus disease 2019 (COVID-19). Patients who underwent transplantation within 30 days of COVID-19 infection comprised the early group, and those who underwent transplantation post-30 days of COVID-19 infection comprised the delayed group. In the early transplantation group, no patient, whether undergoing SOT and HSCT, experienced COVID-19-associated complications. In the delayed transplantation group, one patient each from SOT and HSCT experienced COVID-19-associated complications. Additionally, among early SOT and HSCT recipients, two and six patients underwent transplantation within seven days of COVID-19 diagnosis, respectively. However, no significant differences were observed in the clinical outcomes of these patients compared to those in other patients. Early transplantation following severe acute respiratory syndrome coronavirus 2 infection can be performed without increased risk of COVID-19-associated complications. Therefore, transplantation needs not be delayed by COVID-19 infection.
我们的研究分析了 95 例实体器官移植（SOT）和 78 例造血干细胞移植（HSCT）的 COVID-19 既往感染者。在 COVID-19 感染后 30 天内接受移植的患者为早期组，在 COVID-19 感染后 30 天以上接受移植的患者为延迟组。在早期移植组中，无论是 SOT 还是 HSCT 患者，均未发生 COVID-19 相关并发症。在延迟移植组中，SOT 和 HSCT 各有 1 例患者发生 COVID-19 相关并发症。此外，在早期 SOT 和 HSCT 受者中，分别有 2 例和 6 例患者在 COVID-19 诊断后 7 天内接受了移植。然而，与其他患者相比，这些患者的临床结局并无显著差异。在严重急性呼吸综合征冠状病毒 2 感染后进行早期移植不会增加 COVID-19 相关并发症的风险。因此，COVID-19 感染不应导致移植延迟。
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