Bruss Patrick, Hartle Ryan, Astacio Jennifer, Chauhdri Ammar F
Emergency Medicine, ProMedica Monroe Regional Hospital, Monroe, USA.
Emergency Medicine, University of Michigan, Ann Arbor, USA.
Cureus. 2024 Mar 16;16(3):e56288. doi: 10.7759/cureus.56288. eCollection 2024 Mar.
This is a case of a 20-year-old pregnant female presenting EKG abnormalities associated with an overdose of bupropion. These ECG abnormalities are prolongation of the QRS, prolongation of the corrected QT interval (QTc), right axis deviation, and a terminal R wave. The propagation of electricity through the myocardium is dependent on many factors. It is dependent on the flow of sodium from the extracellular to intracellular space, flow of potassium from intracellular to extracellular space, and ultimately the propagation of the signal at the gap junction by Connexin 43 (Cx-43). We postulate that the ECG abnormalities in this case are secondary to bupropion's effect on the potassium rectifier channels (Kir) and or Cx-43 at the gap junction.
这是一例20岁的怀孕女性，出现与过量服用安非他酮相关的心电图异常。这些心电图异常包括QRS波增宽、校正QT间期（QTc）延长、电轴右偏和终末R波。电在心肌中的传导取决于许多因素。它取决于钠从细胞外间隙向细胞内间隙的流动、钾从细胞内间隙向细胞外间隙的流动，以及最终信号在连接蛋白43（Cx - 43）形成的缝隙连接处的传导。我们推测，本例中的心电图异常继发于安非他酮对钾整流通道（Kir）和/或缝隙连接处Cx - 43的作用。
