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非肌层浸润性膀胱癌经膀胱内卡介苗灌注后发生的胸壁肿瘤。

Chest wall tumor following intravesical BCG instillation for non-muscle invasive bladder cancer.

作者信息

Hartert Marc, Deppe Claudia, Fink Ludger, Kappes Jutta

机构信息

Department of Thoracic Surgery, Katholisches Klinikum Koblenz-Montabaur, Koblenz, Germany.

Department of Internal Medicine and Pneumology, Katholisches Klinikum Koblenz-Montabaur, Koblenz, Germany.

出版信息

J Clin Tuberc Other Mycobact Dis. 2024 Apr 9;35:100438. doi: 10.1016/j.jctube.2024.100438. eCollection 2024 May.

Abstract

bacille Calmette-Guérin (BCG) is the most effective intravesical immunotherapy for non-muscle invasive bladder cancer (NMIBC), administered after its transurethral resection. Although its instillation is generally well tolerated, BCG-related infectious complications may occur in up to 5% of patients. Clinical manifestations may arise in conjunction with initial BCG instillation or develop months or years after the last BCG instillation. The range of presentations and potential severity pose an imminent challenge for clinicians. We present a case of an isolated subcutaneous chest wall abscess in an immunocompetent 52-year-old patient nearly two years after intravesical BCG instillation for NMIBC, an absolute rarity. As the enlarging chest wall tumor may be misinterpreted as malignancy, its expedient diagnosis and prompt treatment are of critical importance.

摘要

卡介苗(BCG)是用于非肌层浸润性膀胱癌(NMIBC)经尿道切除术后最有效的膀胱内免疫疗法。尽管其灌注通常耐受性良好,但高达5%的患者可能会发生卡介苗相关的感染并发症。临床表现可能在初次卡介苗灌注时出现,或在最后一次卡介苗灌注数月或数年后发生。临床表现的范围和潜在严重程度给临床医生带来了紧迫的挑战。我们报告一例52岁免疫功能正常的患者,在膀胱内灌注卡介苗治疗NMIBC近两年后出现孤立的胸壁皮下脓肿,这绝对罕见。由于不断增大的胸壁肿物可能被误诊为恶性肿瘤,其快速诊断和及时治疗至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5d8/11017275/acaf15ab4922/gr1.jpg

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