• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

虾青素通过抑制氧化应激预防棕榈酸致骨质疏松大鼠的骨丢失。

Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress.

机构信息

Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe Shan Xi Road, Wuhu, Anhui, People's Republic of China.

Anhui Province Key Laboratory of Noncoding RNA Basic and Clinical Transformation, No. 2, Zhe Shan Xi Road, Wuhu, Anhui, People's Republic of China.

出版信息

Redox Rep. 2024 Dec;29(1):2333096. doi: 10.1080/13510002.2024.2333096. Epub 2024 Apr 16.

DOI:10.1080/13510002.2024.2333096
PMID:38623993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11025413/
Abstract

OBJECTIVES

The study aimed to assess the role of Astaxanthin (ATX) in palmitic acid(PA) -induced bone loss in Ovariectomized(OVX) rats.

METHODS

In the OVX rat model, we observed that PA affects bone metabolism and accelerates bone loss. Additionally, treatment with ATX was able to suppress the deleterious effects of PA and a simultaneous decrease in serum MDA levels and an increase in SOD was observed.

RESULTS

In addition, rats treated with ATX were observed to have significantly increased bone mass and elevated activity of SIRT1 and SOD2 in bone tissue. When MC3T3-E1 and RAW264.7 cells induced osteoblast and osteoclast differentiation, the ATX intervention was able to significantly restore the restriction of osteogenic differentiation and the up-regulation of osteoclast differentiation with PA therapy. Furthermore, we confirm that PA damage to cells is caused by increased oxidative stress, and that ATX can target and modulate the activity of SIRT1 to regulate the levels of oxidative stress in cells.

CONCLUSION

Summarizing, ATX may inhibit PA-induced bone loss through its antioxidant properties via the SIRT1 signaling pathway.

摘要

目的

本研究旨在评估虾青素（ATX）在棕榈酸（PA）诱导去卵巢（OVX）大鼠骨丢失中的作用。

方法

在 OVX 大鼠模型中，我们观察到 PA 影响骨代谢并加速骨丢失。此外，ATX 的治疗能够抑制 PA 的有害影响，同时观察到血清 MDA 水平降低和 SOD 水平升高。

结果

此外，用 ATX 治疗的大鼠观察到骨量显著增加，骨组织中 SIRT1 和 SOD2 的活性升高。当 MC3T3-E1 和 RAW264.7 细胞诱导成骨细胞和破骨细胞分化时，ATX 干预能够显著恢复 PA 治疗对成骨分化的限制和破骨细胞分化的上调。此外，我们证实 PA 对细胞的损伤是由氧化应激增加引起的，ATX 可以通过靶向和调节 SIRT1 的活性来调节细胞内的氧化应激水平。

结论

总之，ATX 可能通过 SIRT1 信号通路通过其抗氧化特性抑制 PA 诱导的骨丢失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/cded72094339/YRER_A_2333096_F0012_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/5dc23d6a47ea/YRER_A_2333096_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/73383387394c/YRER_A_2333096_F0001_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/c2dfe77cd6e3/YRER_A_2333096_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/fd4b4817e7e4/YRER_A_2333096_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/217f87ba5299/YRER_A_2333096_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/71b38d738b5a/YRER_A_2333096_F0005_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/38f30a7dad4e/YRER_A_2333096_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/3c4ed1e7f0de/YRER_A_2333096_F0007_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/b80b46637790/YRER_A_2333096_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/5dbcf5627297/YRER_A_2333096_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/5a5277ba0cad/YRER_A_2333096_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/cab39deb9b21/YRER_A_2333096_F0011_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/cded72094339/YRER_A_2333096_F0012_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/5dc23d6a47ea/YRER_A_2333096_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/73383387394c/YRER_A_2333096_F0001_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/c2dfe77cd6e3/YRER_A_2333096_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/fd4b4817e7e4/YRER_A_2333096_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/217f87ba5299/YRER_A_2333096_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/71b38d738b5a/YRER_A_2333096_F0005_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/38f30a7dad4e/YRER_A_2333096_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/3c4ed1e7f0de/YRER_A_2333096_F0007_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/b80b46637790/YRER_A_2333096_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/5dbcf5627297/YRER_A_2333096_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/5a5277ba0cad/YRER_A_2333096_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/cab39deb9b21/YRER_A_2333096_F0011_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1222/11025413/cded72094339/YRER_A_2333096_F0012_OC.jpg

相似文献

1
Astaxanthin prevents bone loss in osteoporotic rats with palmitic acid through suppressing oxidative stress.虾青素通过抑制氧化应激预防棕榈酸致骨质疏松大鼠的骨丢失。
Redox Rep. 2024 Dec;29(1):2333096. doi: 10.1080/13510002.2024.2333096. Epub 2024 Apr 16.
2
Protocatechualdehyde inhibits iron overload-induced bone loss by inhibiting inflammation and oxidative stress in senile rats.原儿茶醛通过抑制老年大鼠炎症和氧化应激抑制铁过载诱导的骨丢失。
Int Immunopharmacol. 2024 Nov 15;141:113016. doi: 10.1016/j.intimp.2024.113016. Epub 2024 Aug 24.
3
Niacin treatment prevents bone loss in iron overload osteoporotic rats via activation of SIRT1 signaling pathway.烟酰胺治疗通过激活 SIRT1 信号通路预防铁过载骨质疏松大鼠的骨丢失。
Chem Biol Interact. 2024 Jan 25;388:110827. doi: 10.1016/j.cbi.2023.110827. Epub 2023 Dec 9.
4
Melatonin restores the osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells by preserving SIRT1-mediated intracellular antioxidant properties.褪黑素通过维持 SIRT1 介导的细胞内抗氧化特性来恢复骨质疏松症损伤的骨髓间充质干细胞的成骨潜能。
Free Radic Biol Med. 2020 Jan;146:92-106. doi: 10.1016/j.freeradbiomed.2019.10.412. Epub 2019 Oct 24.
5
Melatonin alleviates hydrogen peroxide induced oxidative damage in MC3T3-E1 cells and promotes osteogenesis by activating SIRT1.褪黑素可减轻过氧化氢诱导的MC3T3-E1细胞氧化损伤，并通过激活SIRT1促进成骨作用。
Free Radic Res. 2022 Jan;56(1):63-76. doi: 10.1080/10715762.2022.2037580. Epub 2022 Feb 10.
6
Silymarin prevents iron overload induced bone loss by inhibiting oxidative stress in an ovariectomized animal model.水飞蓟素通过抑制去卵巢动物模型中的氧化应激来预防铁过载引起的骨质流失。
Chem Biol Interact. 2022 Oct 1;366:110168. doi: 10.1016/j.cbi.2022.110168. Epub 2022 Sep 7.
7
Melatonin prevents bone loss in osteoporotic rats with valproic acid treatment by anti-inflammatory and anti-oxidative stress.褪黑素通过抗炎和抗氧化应激作用预防丙戊酸治疗骨质疏松大鼠的骨丢失。
Int Immunopharmacol. 2024 Nov 15;141:112932. doi: 10.1016/j.intimp.2024.112932. Epub 2024 Aug 17.
8
Resveratrol promotes osteogenesis via activating SIRT1/FoxO1 pathway in osteoporosis mice.白藜芦醇通过激活 SIRT1/FoxO1 通路促进骨质疏松症小鼠的成骨作用。
Life Sci. 2020 Apr 1;246:117422. doi: 10.1016/j.lfs.2020.117422. Epub 2020 Feb 11.
9
Asiatic acid improves high-fat-diet-induced osteoporosis in mice via regulating SIRT1/FOXO1 signaling and inhibiting oxidative stress.齐墩果酸通过调节SIRT1/FOXO1信号通路并抑制氧化应激来改善高脂饮食诱导的小鼠骨质疏松症。
Histol Histopathol. 2022 Aug;37(8):769-777. doi: 10.14670/HH-18-446. Epub 2022 Mar 1.
10
Silibinin-modified Hydroxyapatite coating promotes the osseointegration of titanium rods by activation SIRT1/SOD2 signaling pathway in diabetic rats.水飞蓟宾修饰的羟基磷灰石涂层通过激活 SIRT1/SOD2 信号通路促进糖尿病大鼠钛棒的骨整合。
J Mater Sci Mater Med. 2022 Sep 4;33(9):62. doi: 10.1007/s10856-022-06684-1.

引用本文的文献

1
The Protective Activity of Apigenin Against Bone and Cartilage Diseases.芹菜素对骨骼和软骨疾病的保护作用。
Clin Interv Aging. 2025 Aug 13;20:1235-1251. doi: 10.2147/CIA.S529148. eCollection 2025.
2
Development of fatty acid analogues with potent anabolic effects on bone in male mice.对雄性小鼠骨骼具有强效合成代谢作用的脂肪酸类似物的研发。
Bone Rep. 2025 Jul 30;26:101862. doi: 10.1016/j.bonr.2025.101862. eCollection 2025 Sep.
3
Dietary canthaxanthin improves egg production rate through regulating hepatic lipid metabolism and redox status in indigenous chickens.

本文引用的文献

1
Co-modified 3D printed β-tricalcium phosphate with magnesium and selenium promotes bone defect regeneration in ovariectomized rat.镁和硒共修饰 3D 打印β-磷酸三钙促进去卵巢大鼠骨缺损再生。
J Mater Sci Mater Med. 2023 Jan 9;34(1):7. doi: 10.1007/s10856-022-06708-w.
2
Systemic administration with melatonin in the daytime has a better effect on promoting osseointegration of titanium rods in ovariectomized rats.白天给予褪黑素进行全身给药，对促进去卵巢大鼠钛棒的骨整合具有更好的效果。
Bone Joint Res. 2022 Nov;11(11):751-762. doi: 10.1302/2046-3758.1111.BJR-2022-0017.R2.
3
Silymarin prevents iron overload induced bone loss by inhibiting oxidative stress in an ovariectomized animal model.
日粮角黄素通过调节本地鸡肝脏脂质代谢和氧化还原状态提高产蛋率。
Front Vet Sci. 2025 Jun 5;12:1607039. doi: 10.3389/fvets.2025.1607039. eCollection 2025.
4
The role of palmitoylation modifications in the regulation of bone cell function, bone homeostasis, and osteoporosis.棕榈酰化修饰在骨细胞功能调节、骨稳态和骨质疏松症中的作用。
Bone Joint Res. 2025 May 9;14(5):420-433. doi: 10.1302/2046-3758.145.BJR-2024-0259.R2.
5
Sodium butyrate protect bone mass in lipopolysaccharide-treated rats by reducing oxidative stress and inflammatory.丁酸钠通过降低氧化应激和炎症反应来保护脂多糖处理大鼠的骨量。
Redox Rep. 2024 Dec;29(1):2398891. doi: 10.1080/13510002.2024.2398891. Epub 2024 Sep 16.
6
Potential treatment of glutathione in bullfrogs with abnormal hepatic lipid metabolism revealed by hepatic lipid metabolism and serum metabolomics analysis.基于肝脂质代谢和血清代谢组学分析揭示的牛蛙异常肝脂质代谢的谷胱甘肽潜在治疗作用。
Front Cell Infect Microbiol. 2024 Aug 13;14:1426340. doi: 10.3389/fcimb.2024.1426340. eCollection 2024.
水飞蓟素通过抑制去卵巢动物模型中的氧化应激来预防铁过载引起的骨质流失。
Chem Biol Interact. 2022 Oct 1;366:110168. doi: 10.1016/j.cbi.2022.110168. Epub 2022 Sep 7.
4
Silibinin-modified Hydroxyapatite coating promotes the osseointegration of titanium rods by activation SIRT1/SOD2 signaling pathway in diabetic rats.水飞蓟宾修饰的羟基磷灰石涂层通过激活 SIRT1/SOD2 信号通路促进糖尿病大鼠钛棒的骨整合。
J Mater Sci Mater Med. 2022 Sep 4;33(9):62. doi: 10.1007/s10856-022-06684-1.
5
Probucol promotes osteoblasts differentiation and prevents osteoporosis development through reducing oxidative stress.普罗布考通过减少氧化应激促进成骨细胞分化，预防骨质疏松症的发生。
Mol Med. 2022 Jun 28;28(1):75. doi: 10.1186/s10020-022-00503-7.
6
Apoptosis-Inducing Factor 2 (AIF-2) Mediates a Caspase-Independent Apoptotic Pathway in the Tropical Sea Cucumber ().凋亡诱导因子 2（AIF-2）在热带海参（）中介导一种不依赖半胱天冬酶的凋亡途径。
Int J Mol Sci. 2022 Mar 10;23(6):3008. doi: 10.3390/ijms23063008.
7
Inhibitory Effects of Astaxanthin on CML-HSA-Induced Inflammatory and RANKL-Induced Osteoclastogenic Gene Expression in RAW 264.7 Cells.虾青素对CML-HSA诱导的RAW 264.7细胞炎症及RANKL诱导的破骨细胞生成基因表达的抑制作用
Biomedicines. 2021 Dec 27;10(1):54. doi: 10.3390/biomedicines10010054.
8
Silibinin Can Promote Bone Regeneration of Selenium Hydrogel by Reducing the Oxidative Stress Pathway in Ovariectomized Rats.水飞蓟宾可通过降低去卵巢大鼠的氧化应激途径来促进硒水凝胶的骨再生。
Calcif Tissue Int. 2022 Jun;110(6):723-735. doi: 10.1007/s00223-021-00936-y. Epub 2022 Jan 20.
9
Hydrogel contained valproic acid accelerates bone-defect repair via activating Notch signaling pathway in ovariectomized rats.载有丙戊酸的水凝胶通过激活去卵巢大鼠的 Notch 信号通路加速骨缺损修复。
J Mater Sci Mater Med. 2021 Dec 23;33(1):4. doi: 10.1007/s10856-021-06627-2.
10
Notoginsenoside R1 attenuates oxidative stress-induced osteoblast dysfunction through JNK signalling pathway.三七总皂苷 R1 通过 JNK 信号通路减轻氧化应激诱导的成骨细胞功能障碍。
J Cell Mol Med. 2021 Dec;25(24):11278-11289. doi: 10.1111/jcmm.17054. Epub 2021 Nov 16.