Schmidt Azevedo Paula, Fock Ricardo Ambrosio, Pereira Filipe Leal, Dos Santos Priscila Portugal, Ferro Flavio Cruz, Sacco Nataly, Polegato Bertha Furlan, Zornoff Leonardo Mamede, Okoshi Marina Politi, Achterberg Wilco, de Paiva Sergio Rupp
Internal Medicine Department, Botucatu Medical School, São Paulo State University, Av. Prof Mario Rubens Guimarães Montenegro s/n, Botucatu, 18618-687 Brazil.
Experimental Hematology Laboratory, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Nutrire. 2021;46(1):1. doi: 10.1186/s41110-020-00131-3. Epub 2021 Jan 6.
Considering the COVID-19 pandemic, vitamin D is a target of research and speculation. Lockdown or home isolation reduces sunlight exposition and increases the risk of vitamin D deficiency. Special attention is needed for older people at risk of both severe forms of COVID-19 and vitamin D deficiency. This review aims to highlight the association of vitamin D and COVID-19 in two instances, the direct influence of vitamin D on the immune system, and the indirect risks for other vitamin D deficiency-related diseases, such as musculoskeletal properties in older persons.
We performed a narrative review.
Whether vitamin D deficiency is associated with COVID-19 poor prognosis, and if vitamin D supplementation may improve the post-infection outcomes is still unclear. In any case, the pandemic generates indirect burden, such as the sequence: home isolation, low sunlight exposition, vitamin D deficiency, and fragility fractures.
Therefore, it is time to debate how to optimize vitamin D status in older people, especially during the COVID-19 pandemic.
鉴于新冠疫情，维生素D成为研究和推测的对象。封锁或居家隔离减少了阳光照射，增加了维生素D缺乏的风险。对于同时面临严重新冠病毒感染和维生素D缺乏风险的老年人，需要给予特别关注。本综述旨在突出维生素D与新冠病毒感染在两方面的关联，一是维生素D对免疫系统的直接影响，二是维生素D缺乏相关其他疾病的间接风险，如老年人的肌肉骨骼状况。
我们进行了一项叙述性综述。
维生素D缺乏是否与新冠病毒感染的不良预后相关，以及补充维生素D是否能改善感染后的结局仍不明确。无论如何，疫情产生了间接负担，例如居家隔离、阳光照射不足、维生素D缺乏和脆性骨折这样的连锁反应。
因此，是时候讨论如何优化老年人的维生素D水平了，尤其是在新冠疫情期间。
