Stohlman S A, Matsushima G K, Casteel N, Frelinger J A
Eur J Immunol. 1985 Sep;15(9):913-6. doi: 10.1002/eji.1830150909.
SJL mice exhibit a strain-specific age-dependent delay in the maturation of delayed-type hypersensitivity (DTH) responsiveness. They do not attain "adult" levels of DTH responsiveness until the 10th week of age, which is 4 to 6 weeks later than the other strains of mice tested. In this report we demonstrate that spleen cells, resident peritoneal cells and thioglycollate-elicited peritoneal exudate cells are all able to transfer DTH responsiveness from naive 12-week-old DTH responders to 6-week-old nonresponders. Transfer prior to immunization was more efficient at eliciting a response than transfer after immunization. As few as 5 X 10(4) cells from 12-week-old SJL mice can adoptively transfer responsiveness to unresponsive 6-week-old animals. The active cell was found to be adherent, radiation (2000 rds) resistant, I-A+, Thy-1- and Mac-1+. I-A compatibility between the adoptively transferred population and the nonresponder mice is required. These data suggest that young adult SJL mice lack a functional population of antigen-presenting cells specific for DTH and that the appearance of these cells is under maturational control.
SJL小鼠在迟发型超敏反应（DTH）反应成熟过程中表现出品系特异性的年龄依赖性延迟。它们直到10周龄时才达到DTH反应的“成年”水平，这比所测试的其他品系小鼠晚4至6周。在本报告中，我们证明脾细胞、驻留腹膜细胞和巯基乙酸诱导的腹膜渗出细胞都能够将DTH反应从12周龄的未致敏DTH反应者转移到6周龄的无反应者。免疫前转移比免疫后转移在引发反应方面更有效。来自12周龄SJL小鼠的低至5×10⁴个细胞就能将反应性过继转移给无反应的6周龄动物。发现活性细胞具有贴壁性、抗辐射（2000拉德）、I-A⁺、Thy-1⁻和Mac-1⁺。过继转移群体与无反应小鼠之间需要I-A相容性。这些数据表明，年轻的成年SJL小鼠缺乏对DTH具有特异性的功能性抗原呈递细胞群体，并且这些细胞的出现受成熟控制。
