Vastag E, Matthys H, Köhler D, Gronbeck L, Daikeler G
Eur J Respir Dis Suppl. 1985;139:93-100.
On 17 ex-smokers (7 without chronic bronchitis, 10 with chronic bronchitis) and 48 smokers (13 without chronic bronchitis, 35 with chronic bronchitis) we analyzed the correlation between smoking habits (pack years, smoking and ex-smoking time), mucociliary clearance rate (mC) and airways obstruction. The mC was measured with 99mTc tagged monodisperse erythrocytes. The static and dynamic lung volumes, the maximal expiratory flow volume curve and the airway resistance were measured by whole body plethysmography. The ex-smokers without chronic bronchitis showed the same mucociliary clearance rate (t-mC in 1 h = 38.3 +/- 10.3%) as the 80 control subjects who never smoked (t-mC in 1 h = 36.9 +/- 12.6%). But the subjects who never smoked showed less airway obstruction. The mucociliary clearance rate in normal subjects who never smoked is a function of age: t-mC in 1 h = -0.37 X age + 53; c-mC in 1 h = -0.45 X age + 73; p-mC in 1 h = -0.25 X age + 38. The smokers without chronic bronchitis showed normal ventilatory function tests but a lower mC rate (t-mC in 1 h = 27.8 +/- 12.3%) than the healthy ex-smokers and the control subjects who never smoked (p less than 0.01). The ex-smokers and smokers with chronic bronchitis had a lower mC rate (t-mC in 1 h = 21.2 +/- 11.3% and 18.1 +/- 9.1) and more airway obstruction (p less than 0.001) than the subjects who did not report any symptoms of chronic bronchitis. The ex-smokers with persistent symptoms of chronic bronchitis showed the severest degree of airways obstruction. The smokers with chronic bronchitis showed the most delayed central mC (c-mC) rate, but less airway obstruction than the ex-smokers with persistent symptoms of chronic bronchitis. The smoking habits (pack years) correlated with the decreased mC rate (p less than 0.01) and the degree of airways obstruction (p less than 0.001).
我们对17名已戒烟者（7名无慢性支气管炎，10名有慢性支气管炎）和48名吸烟者（13名无慢性支气管炎，35名有慢性支气管炎）的吸烟习惯（吸烟包年数、吸烟及戒烟时间）、黏液纤毛清除率（mC）与气道阻塞之间的相关性进行了分析。黏液纤毛清除率采用99mTc标记的单分散红细胞进行测量。静态和动态肺容量、最大呼气流量容积曲线及气道阻力通过全身体积描记法进行测量。无慢性支气管炎的已戒烟者的黏液纤毛清除率（1小时转运性黏液纤毛清除率=t-mC=38.3±10.3%）与80名从不吸烟的对照者（1小时转运性黏液纤毛清除率=t-mC=36.9±12.6%）相同。但从不吸烟的受试者气道阻塞程度较轻。从不吸烟的正常受试者的黏液纤毛清除率是年龄的函数：1小时转运性黏液纤毛清除率=t-mC=-0.37×年龄+53；1小时中央性黏液纤毛清除率=c-mC=-0.45×年龄+73；1小时外周性黏液纤毛清除率=p-mC=-0.25×年龄+38。无慢性支气管炎的吸烟者通气功能测试正常，但黏液纤毛清除率（1小时转运性黏液纤毛清除率=t-mC=27.8±12.3%）低于健康已戒烟者和从不吸烟的对照者（p<0.01）。有慢性支气管炎的已戒烟者和吸烟者的黏液纤毛清除率较低（1小时转运性黏液纤毛清除率=t-mC分别为21.2±11.3%和18.1±9.1），气道阻塞更严重（p<0.001），相比于未报告任何慢性支气管炎症状的受试者。有慢性支气管炎持续症状的已戒烟者气道阻塞程度最严重。有慢性支气管炎的吸烟者中央性黏液纤毛清除率（c-mC）延迟最明显，但气道阻塞程度低于有慢性支气管炎持续症状的已戒烟者。吸烟习惯（吸烟包年数）与黏液纤毛清除率降低（p<0.01）及气道阻塞程度（p<0.001）相关。
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