Department of Internal Medicine, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.
Department of Community Medicine, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.
Kathmandu Univ Med J (KUMJ). 2023 Apr-Jun;21(82):144-148.
Background Fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) are commonly used for diagnosing diabetes mellitus in Nepal. Though HbA1c criteria are convenient for diagnosis there is a discrepancy between the fasting plasma glucose and HbA1c for diagnosis. Objective To assess the comparability between fasting plasma glucose and glycated hemoglobin levels in the new-onset diabetes mellitus. Method This is a hospital-based descriptive cross-sectional study including 128 newly diagnosed diabetes mellitus conducted at Dhulikhel Hospital, Kathmandu University Hospital. New onset diabetes patients above 18 years of age who met inclusion criteria were included. The clinical characteristics and biochemical parameters were analyzed. Statistical analysis was done using student's t-test and correlation coefficient. Result There were 128 newly diagnosed diabetes mellitus patients included in the study among which 57.0% were males with a mean age of 49.48±11.40 years. The mean fasting plasma glucose, postprandial sugar (PPBS), and glycated hemoglobin were 205.54±88.93 mg/dL, 331.08±146.61 mg/dL, and 9.59±2.70% respectively. Diabetes was diagnosed using fasting plasma glucose, and glycated hemoglobin criteria in 84.4% and 90.6% of patients. In new-onset diabetic patients, 76.56% of patients had both elevated levels of fasting plasma glucose and glycated hemoglobin. Of the diabetic patients who had fasting plasma glucose ≥126 mg/dL, 90.7% of patients had HbA1c ≥ 6.5% whereas 1.6% of new-onset diabetes had < 126 mg/dL and glycated hemoglobin < 6.5%. There was a strong correlation between fasting plasma glucose and glycated hemoglobin (r=0.723; p<0.01). Conclusion Both fasting plasma glucose and glycated hemoglobin tests have to be used together for diagnosing diabetes mellitus.
背景 空腹血糖（FPG）和糖化血红蛋白（HbA1c）常用于尼泊尔的糖尿病诊断。虽然 HbA1c 标准便于诊断，但 FPG 和 HbA1c 之间的诊断结果存在差异。目的 评估新诊断的糖尿病患者中空腹血糖和糖化血红蛋白水平的可比性。方法 这是一项在加德满都大学医院 Dhulikhel 医院进行的以医院为基础的描述性横断面研究，共纳入 128 例新诊断的糖尿病患者。纳入符合纳入标准的年龄大于 18 岁的新发糖尿病患者。分析临床特征和生化参数。使用学生 t 检验和相关系数进行统计分析。结果 本研究共纳入 128 例新诊断的糖尿病患者，其中男性占 57.0%，平均年龄为 49.48±11.40 岁。空腹血糖、餐后血糖（PPBS）和糖化血红蛋白的平均值分别为 205.54±88.93mg/dL、331.08±146.61mg/dL 和 9.59±2.70%。根据空腹血糖和糖化血红蛋白标准，分别有 84.4%和 90.6%的患者被诊断为糖尿病。在新诊断的糖尿病患者中，76.56%的患者空腹血糖和糖化血红蛋白均升高。在空腹血糖≥126mg/dL 的糖尿病患者中，90.7%的患者 HbA1c≥6.5%，而 1.6%的新发糖尿病患者空腹血糖<126mg/dL 且糖化血红蛋白<6.5%。空腹血糖和糖化血红蛋白之间存在很强的相关性（r=0.723；p<0.01）。结论 诊断糖尿病时，必须同时进行空腹血糖和糖化血红蛋白检查。
