研究锂对甲基苯丙胺诱导的大鼠空间记忆损伤的促进作用。
Investigating Facilitatory Effects of Lithium on Methamphetamine-induced Spatial Memory Impairments in Rat.
作者信息
Ghazvini Hamed, Tirgar Fatemeh, Khodamoradi Mehdi, Seyedhosseini Tamijani Seyedeh Masoumeh, Niknamfar Saba, Akbari Esmaeil, Nekahi Mohammad, Tarjani Nabiollah, Ghalehnoei Hossein, Rouhi Ardeshiri Motahareh
机构信息
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Basic Clin Neurosci. 2023 Sep-Oct;14(5):605-614. doi: 10.32598/bcn.2022.2297.1. Epub 2023 Sep 1.
INTRODUCTION
It has long been known that Methamphetamine (MA), as a psychostimulant, leads to long-lasting cognitive deficits. Previous studies have shown that lithium, a mood stabilizer, could facilitate cognitive ability in most of brain diseases. In current study the effects of lithium on spatial memory, hippocampal apoptosis and brain edema in METH-exposed rats are investigated.
METHODS
The present study 32 Wistar rats were used to examine the effects of lithium on spatial memory by the Morris water maze, hippocampal apoptosis using the TUNEL assay, and brain edema following MA administrations.
RESULTS
The findings indicated that treatment with lithium significantly ameliorated spatial learning and memory impairment in MA-treated rats. In addition, the findings showed that treatment with lithium significantly reduced brain edema and apoptosis in the CA1 neurons in MA -exposed rats.
CONCLUSION
The results show that treatment with lithium can partially ameliorate the MA-induced neurocognitive deficits in rats, which may be related to its protective effect in the hippocampus.
引言
长期以来，人们都知道甲基苯丙胺（MA）作为一种精神兴奋剂会导致长期的认知缺陷。先前的研究表明，锂盐作为一种情绪稳定剂，在大多数脑部疾病中都能促进认知能力。在本研究中，我们调查了锂盐对甲基苯丙胺暴露大鼠的空间记忆、海马细胞凋亡和脑水肿的影响。
方法
本研究使用32只Wistar大鼠，通过莫里斯水迷宫检测锂盐对空间记忆的影响，使用TUNEL法检测海马细胞凋亡，并检测甲基苯丙胺给药后的脑水肿情况。
结果
研究结果表明，锂盐治疗显著改善了甲基苯丙胺处理大鼠的空间学习和记忆障碍。此外，研究结果还表明，锂盐治疗显著减轻了甲基苯丙胺暴露大鼠CA1神经元的脑水肿和细胞凋亡。
结论
结果表明，锂盐治疗可以部分改善大鼠中甲基苯丙胺诱导的神经认知缺陷，这可能与其对海马体的保护作用有关。
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