Department of Pathology, University of California San Francisco, San Francisco, CA, USA.
Histopathology. 2024 Aug;85(2):215-223. doi: 10.1111/his.15194. Epub 2024 Apr 17.
The current understanding of inflammatory myofibroblastic tumours (IMTs) of the gynaecological tract has recently been enhanced by their increased recognition. This increase is largely due to greater accessibility to RNA-based molecular assays used to identify their defining ALK rearrangements. This review summarises the clinical characteristics, morphological spectrum, immunohistochemical profile and molecular underpinnings of uterine IMT. Additionally, this review discusses practical diagnostic considerations including overlap between uterine IMT and smooth muscle tumours as well as pregnancy-associated uterine IMT. Finally, we highlight recent literature demonstrating the potential for aggressive behaviour in uterine IMT, including a novel risk stratification model for identifying high-risk IMT.
目前，人们对妇科生殖道炎性肌纤维母细胞瘤（IMTs）的认识有所提高，这主要是因为越来越多的人可以使用基于 RNA 的分子检测来识别其标志性的 ALK 重排。本文总结了子宫 IMT 的临床特征、形态学谱、免疫组织化学特征和分子基础。此外，本文还讨论了实际诊断中需要考虑的问题，包括子宫 IMT 与平滑肌肿瘤之间的重叠以及与妊娠相关的子宫 IMT。最后，我们强调了最近的文献表明，子宫 IMT 具有侵袭性行为的潜力，包括一种新的风险分层模型，用于识别高危 IMT。
