Chen Wenhuang, Lin Yijian, Huang Hongbo, Cai Maosheng, Lin Dongheng, Su Milong, Su Zhijun, Zhuang Xibin, Yu Xueping
Department of Infectious Disease, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, China.
These authors contributed equally to this work.
Infect Microbes Dis. 2021 Jan 15;3(1):32-40. doi: 10.1097/IM9.0000000000000048. eCollection 2021 Mar.
Coronavirus disease 2019 (COVID-19) has spread throughout China. However, information about COVID-19 in cities and regions outside Wuhan is limited and the indicators that predict the length of hospital stay for patients with COVID-19 are unclear. Therefore, we collected clinical data from 47 patients with COVID-19 in Quanzhou City. The median age was 38 years [interquartile range (IQR): 31-50 years], and 24 (51%) were male. There were 8 mild, 36 moderate, and 3 severe/critical cases. The median interval from exposure to disease onset was 13 days (IQR: 8-18 days). The incidence of severe/critical cases was 33% (3/10) in patients with hypertension. Common symptoms included fever (83%), cough (77%), fatigue (40%), a sore, dry throat (28%), and diarrhea (21%). One patient (2%) developed respiratory distress syndrome on day 13 of inpatient treatment. Six patients had leukopenia, 17 had elevated C-reactive protein (CRP), and 8 had lymphocytopenia and elevated lactate dehydrogenase (LDH). The median length of hospitalization was 22 days (IQR: 16-30 days). Dynamic monitoring of LDH, CRP, and neutrophil-lymphocyte ratio predicted whether length of hospitalization would exceed 21 days. Most patients presented with mild and moderate disease. Patients with hypertension were more likely to become severe or critical. Dynamic monitoring of LDH, CRP, and neutrophil-lymphocyte ratio levels can help predict delayed discharge from the hospital.
2019冠状病毒病（COVID-19）已在中国各地传播。然而，武汉以外城市和地区关于COVID-19的信息有限，且预测COVID-19患者住院时间的指标尚不清楚。因此，我们收集了泉州市47例COVID-19患者的临床资料。中位年龄为38岁[四分位间距（IQR）：31 - 50岁]，男性24例（51%）。其中轻症8例，中症36例，重症/危重症3例。从接触到发病的中位间隔时间为13天（IQR：8 - 18天）。高血压患者中重症/危重症的发生率为33%（3/10）。常见症状包括发热（83%）、咳嗽（77%）、乏力（40%）、咽痛咽干（28%）和腹泻（21%）。1例患者（2%）在住院治疗第13天出现呼吸窘迫综合征。6例患者白细胞减少，17例C反应蛋白（CRP）升高，8例淋巴细胞减少且乳酸脱氢酶（LDH）升高。中位住院时间为22天（IQR：16 - 30天）。对LDH、CRP和中性粒细胞 - 淋巴细胞比值进行动态监测可预测住院时间是否会超过21天。大多数患者表现为轻症和中症。高血压患者更易发展为重症或危重症。对LDH、CRP和中性粒细胞 - 淋巴细胞比值水平进行动态监测有助于预测出院延迟情况。
