血清尿酸与老年人群功能障碍的关系：一项基于人群的研究。
Association of serum uric acid with functional disability in older subjects: a population-based study.
机构信息
Department of Medicine, Research Unit of Geriatrics, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, Roma, 21 - 00128, Italy.
Operative Research Unit of Geriatrics, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, Roma, 200 - 00128, Italy.
出版信息
Aging Clin Exp Res. 2024 Apr 17;36(1):96. doi: 10.1007/s40520-024-02746-2.
BACKGROUND
The role of serum uric acid (SUA) in the development of adverse health outcomes in advanced age is still uncertain.
AIMS
The aim of the study was to assess the association of disability with SUA levels in older community-dwelling subjects.
METHODS
We assessed the association of disability with SUA in all 351 inhabitants of Tuscania (Italy) aged 75+. Functional ability was estimated using the instrumental activities of daily living (IADLs).
RESULTS
In logistic regression, increasing SUA levels were associated with disability (OR = 1.22; 95%CI = 1.01-1.48; P = .036), after adjusting. The association was independent of both gender and age (P for interaction > 0.050). SUA levels above 5.5 mg/dL best predicted disability.
CONCLUSIONS
In older subjects, SUA levels are associated with disability; the cut off level above 5.5 mg/dL might be adopted in pharmacological trials aiming at reducing the incidence and progression of disability by reducing SUA, and for identifying subjects at increased risk of disability.
背景
血清尿酸（SUA）在高龄人群中对健康不良结局的作用仍不确定。
目的
本研究旨在评估残疾与老年社区居民 SUA 水平之间的关系。
方法
我们评估了所有 351 名居住在意大利托斯卡纳的 75 岁及以上居民的残疾与 SUA 之间的关系。使用工具性日常生活活动（IADLs）来评估功能能力。
结果
在调整性别和年龄后，逻辑回归显示 SUA 水平升高与残疾相关（OR=1.22；95%CI=1.01-1.48；P=0.036）。这种关联不受性别和年龄的影响（交互作用 P>0.050）。SUA 水平超过 5.5mg/dL 能最好地预测残疾。
结论
在老年人中，SUA 水平与残疾相关；在通过降低 SUA 来减少残疾的发生率和进展，以及识别残疾风险增加的人群方面，5.5mg/dL 以上的截断值可能被采用。
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