Area di Geriatria, Campus Bio-Medico University, Via Álvaro del Portillo, 200, 00128 Rome, Italy.
Geriatric Rehabilitation Unit, Azienda Sanitaria di Firenze, Florence, Italy.
Clin Nutr. 2014 Aug;33(4):626-33. doi: 10.1016/j.clnu.2013.08.005. Epub 2013 Aug 23.
BACKGROUND & AIMS: Metabolic syndrome (MetS) is associated with incident disability in middle-aged subjects. We evaluated the association of MetS with functional ability in an older population.
We enrolled 1155 participants aged 65+, derived from the InCHIANTI study, and followed for 3 years. MetS was diagnosed according to the National Cholesterol Education Program's ATP-III criteria. Functional ability was estimated using the Katz's activities of daily living (ADLs), and the Lawton and Brody for the instrumental activities of daily living (IADLs) scales. The association between disability and MetS at baseline and after follow-up was assessed by logistic regression.
At baseline, MetS was associated with reduced probability of ADLs disability among participants aged 74+ (OR = .33, 95% CI = .14-.77; p = .010), but not in younger (5.08, 95% CI = .88-29.24; p = .069). Also, MetS was associated with reduced probability of incident ADLs disability (OR = .61, 95% CI .41-.91; p = .016), but neither with prevalent, nor incident IADLs disability.
In older persons, MetS is associated with reduced probability of prevalent and incident ADLs disability. Whether older persons with MetS should receive treatment and whether the current diagnostic criteria for MetS apply to older individuals need further investigation.
代谢综合征（MetS）与中年人群的残疾发生有关。我们评估了代谢综合征与老年人群功能能力的关系。
我们纳入了来自 INCHIANTI 研究的 1155 名年龄在 65 岁以上的参与者，并进行了 3 年的随访。代谢综合征按照国家胆固醇教育计划 ATP-III 标准进行诊断。功能能力使用 Katz 的日常生活活动（ADL）和 Lawton 和 Brody 的工具性日常生活活动（IADL）量表进行评估。使用逻辑回归评估基线和随访后残疾与代谢综合征之间的关系。
基线时，在 74 岁以上的参与者中，代谢综合征与 ADL 残疾的可能性降低相关（OR =.33，95%CI =.14-.77；p =.010），但在较年轻的参与者中则无相关性（5.08，95%CI =.88-29.24；p =.069）。此外，代谢综合征与 ADL 新发残疾的可能性降低相关（OR =.61，95%CI.41-.91；p =.016），但与 ADL 现患残疾或 IADL 新发残疾均无相关性。
在老年人中，代谢综合征与 ADL 现患和新发残疾的可能性降低相关。是否应给予老年代谢综合征患者治疗以及当前的代谢综合征诊断标准是否适用于老年人，需要进一步研究。
