Kosaka Naoki, Uchiyama Takanori, Onozawa Masahiro, Nagai Jun, Koya Jiro, Ishizaka Suguru, Nagai Toshiyuki, Ikebe Yohei, Kato Kenjiro, Tanei Zen-Ichi, Sakakibara-Konishi Jun, Hasegawa Yuta, Ohigashi Hiroyuki, Goto Hideki, Hashimoto Daigo, Ujiie Hideki, Hirano Satoshi, Konno Satoshi, Anzai Toshihisa, Taniguchi Koji, Tanaka Shinya, Teshima Takanori
Clinical Training Center, Hokkaido University Hospital, Japan.
Department of Hematology, Hokkaido University Hospital, Japan.
Intern Med. 2024 Dec 15;63(24):3359-3365. doi: 10.2169/internalmedicine.3505-24. Epub 2024 Apr 16.
We herein present a fatal case of constrictive pericarditis (CP) due to acute myelomonocytic leukemia (AMML) in a patient who initially complained of an acute onset of chest pain two days after coronavirus disease 2019 vaccination. An autopsy revealed pericardial infiltration of leukemic cells. CP is rarely associated with leukemia and only 14 cases have been reported in the literature. The etiology of CP in previous reports included leukemic infiltration, graft-versus-host disease, drug-induced, post-radiation, autoimmune, and otherwise unidentified. This case indicates that leukemic infiltration can cause CP and that clinicians should include leukemia in the differential diagnosis of CP.
我们在此报告一例因急性粒单核细胞白血病（AMML）导致缩窄性心包炎（CP）的致命病例，该患者最初在2019年冠状病毒病疫苗接种两天后主诉急性胸痛发作。尸检显示心包有白血病细胞浸润。CP很少与白血病相关，文献中仅报道过14例。既往报告中CP的病因包括白血病浸润、移植物抗宿主病、药物诱导、放疗后、自身免疫性以及其他不明原因。该病例表明白血病浸润可导致CP，临床医生在CP的鉴别诊断中应考虑白血病。
