Reproductive Medicine Center, Zhoushan Maternal and Child Health Care Hospital, Zhoushan, Zhejiang, China.
Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Drug Discov Ther. 2024 Jun 6;18(2):80-88. doi: 10.5582/ddt.2024.01007. Epub 2024 Apr 17.
Tuberculosis is a chronic infectious disease caused by mycobacterium tuberculosis infection. In the world, tuberculosis is an important factor affecting women's reproductive health, which can cause reproductive tract anatomy abnormalities, embryo implantation obstacles, ovarian reserve and ovulation dysfunction, leading to female infertility. This group of women usually need to seek assisted reproductive technology to conceive. Latent tuberculosis infection during pregnancy has no clinical manifestation, but may develop into active tuberculosis, leading to adverse pregnancy outcomes. Most pregnant women do not need to be treated for latent tuberculosis infection, unless they are combined with high-risk factors for tuberculosis progress, but they need close follow-up. Early diagnosis and treatment of active tuberculosis in pregnancy can reduce the incidence rate and mortality of pregnant women and newborns, and treatment needs multidisciplinary cooperation.
结核病是由结核分枝杆菌感染引起的慢性传染病。在全球范围内，结核病是影响女性生殖健康的重要因素，可导致生殖道解剖结构异常、胚胎着床障碍、卵巢储备和排卵功能障碍，进而导致女性不孕。这部分女性通常需要寻求辅助生殖技术来妊娠。妊娠期间潜伏性结核感染无临床表现，但可能发展为活动性结核，导致不良妊娠结局。大多数孕妇无需治疗潜伏性结核感染，除非合并结核进展的高危因素，但需要密切随访。妊娠合并活动性结核病的早期诊断和治疗可降低孕妇和新生儿的发病率和死亡率，治疗需要多学科合作。
