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负载于FeO@SiO纳米颗粒上的烷基硫酸氢铵：用于多组分制备新型四唑并[1,5-a]嘧啶-6-甲酰胺衍生物的高效催化剂。

Alkyl ammonium hydrogen sulfate immobilized on FeO@SiO nanoparticles: a highly efficient catalyst for the multi-component preparation of novel tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives.

作者信息

Khalaj Mehdi, Musavi Seyed Mahmoud, Ghashang Majid

机构信息

Department of Chemistry, Islamic Azad University, Buinzahra Branch, Buinzahra, Iran.

Department of Chemistry, Najafabad Branch, Islamic Azad University, Najafabad, Iran.

出版信息

Sci Rep. 2024 Apr 17;14(1):8870. doi: 10.1038/s41598-024-59096-2.

DOI:10.1038/s41598-024-59096-2
PMID:38632295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11024118/
Abstract

In this, a three-component reaction for the preparation of novel tetrazolo[1,5-a]pyrimidine-6-carboxamide derivatives from N,N'-(sulfonylbis(1,4-phenylene))bis(3-oxobutanamide), aldehydes and 1H-tetrazol-5-amine is reported. The application of FeO@SiO-(PP)(HSO) (A) as a catalyst afforded the desired products (a-a) in high yields in DMF as solvent as well as under solvent-free conditions.

摘要

在此，报道了一种由N,N'-（磺酰基双（1,4-亚苯基））双（3-氧代丁酰胺）、醛和1H-四唑-5-胺制备新型四唑并[1,5-a]嘧啶-6-甲酰胺衍生物的三组分反应。以FeO@SiO-(PP)(HSO)（A）为催化剂，在DMF作为溶剂以及无溶剂条件下，均能以高产率得到所需产物（a-a）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/26214885545a/41598_2024_59096_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/fb5872cf729e/41598_2024_59096_Fig3_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/a16c8e7bf7fc/41598_2024_59096_Sch3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/26214885545a/41598_2024_59096_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/15aa0edadfa7/41598_2024_59096_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/5a882165ee64/41598_2024_59096_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/164d93243d36/41598_2024_59096_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/45363d27b401/41598_2024_59096_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/fb5872cf729e/41598_2024_59096_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/fa06f72eb601/41598_2024_59096_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/178c373cf0e4/41598_2024_59096_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/2c19e4cbe5af/41598_2024_59096_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/a16c8e7bf7fc/41598_2024_59096_Sch3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cfa/11024118/26214885545a/41598_2024_59096_Fig7_HTML.jpg

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