骨关节炎与高血压：观察性研究和孟德尔随机化分析。

Osteoarthritis and hypertension: observational and Mendelian randomization analyses.

机构信息

Departments of Cardiology, Liuzhou People's Hospital, 8 Wenchang Road, Liuzhou, Guangxi, 545006, People's Republic of China.

出版信息

Arthritis Res Ther. 2024 Apr 17;26(1):88. doi: 10.1186/s13075-024-03321-w.

DOI:10.1186/s13075-024-03321-w

PMID:38632649

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11022320/

Abstract

BACKGROUND

The association between osteoarthritis (OA) and hypertension is a subject of ongoing debate in observational research, and the underlying causal relationship between them remains elusive.

METHODS

This study retrospectively included 24,871 participants in the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020. Weighted logistic regression was performed to investigate the connection between OA and hypertension. Additionally, Mendelian randomization (MR) analysis was conducted to explore the potential causal relationship between OA and hypertension.

RESULTS

In the NHANES data, after adjusting for multiple confounding factors, there was no significant relationship between OA and hypertension (OR 1.30, 95% CI, 0.97-1.73, P = 0.089). However, among males, OA appeared to be associated with a higher risk of hypertension (OR 2.25, 95% CI, 1.17-4.32, P = 0.019). Furthermore, MR results indicate no relationship between multiple OA phenotypes and hypertension: knee OA (IVW, OR 1.024, 95% CI: 0.931-1.126, P = 0.626), hip OA (IVW, OR 0.990, 95% CI: 0.941-1.042, P = 0.704), knee or hip OA (IVW, OR 1.005, 95% CI: 0.915-1.105, P = 0.911), and OA from UK Biobank (IVW, OR 0.796, 95% CI: 0.233-2.714, P = 0.715). Importantly, these findings remained consistent across different genders and in reverse MR.

CONCLUSIONS

Our study found that OA patients had a higher risk of hypertension only among males in the observational study. However, MR analysis did not uncover any causal relationship between OA and hypertension.

摘要

背景

骨关节炎（OA）与高血压之间的关联是观察性研究中持续争论的问题，它们之间潜在的因果关系仍然难以捉摸。

方法

本研究回顾性纳入了 2013 年至 2020 年全国健康和营养调查（NHANES）中的 24871 名参与者。采用加权逻辑回归分析 OA 与高血压之间的关系。此外，还进行了孟德尔随机分析（MR）以探讨 OA 与高血压之间潜在的因果关系。

结果

在 NHANES 数据中，调整了多个混杂因素后，OA 与高血压之间无显著相关性（OR 1.30，95%CI，0.97-1.73，P=0.089）。然而，在男性中，OA 似乎与高血压的风险增加有关（OR 2.25，95%CI，1.17-4.32，P=0.019）。此外，MR 结果表明，多种 OA 表型与高血压之间无关联：膝关节 OA（IVW，OR 1.024，95%CI：0.931-1.126，P=0.626），髋关节 OA（IVW，OR 0.990，95%CI：0.941-1.042，P=0.704），膝关节或髋关节 OA（IVW，OR 1.005，95%CI：0.915-1.105，P=0.911），以及来自 UK Biobank 的 OA（IVW，OR 0.796，95%CI：0.233-2.714，P=0.715）。重要的是，这些发现在不同性别和反向 MR 中均保持一致。