Kumar P, Leech S H, Gonzalez F M, Kodlin D
Proc Clin Dial Transplant Forum. 1978;8:90-2.
A review of data from 22 hospitals in the U.S. and Canada, comprised of information on 1700 kidney transplant patients, shows a consistent pattern with respect to usage of steroids both as routine treatment and for rejection episodes. High doses are associated with greater patient mortality. Graft survival is also adversely affected by very high doses, but only in the immediate post-transplant period. Our data suggest that for optimal graft and patient survival the dosage of steroids should be less than 150 mg/day of methylprednisolone on days 1-3, less than 50 mg/day of prednisone on days 4-21, less than 30 mg/day on days 22-30, and less than 20 mg/day between one mo and one yr.
一项对美国和加拿大22家医院数据的回顾，这些数据包含1700名肾移植患者的信息，显示出在类固醇作为常规治疗以及用于治疗排斥反应时的使用情况呈现出一致模式。高剂量与更高的患者死亡率相关。极高剂量也会对移植物存活产生不利影响，但仅在移植后的即刻阶段。我们的数据表明，为了实现最佳的移植物和患者存活，在第1 - 3天，类固醇的剂量应低于150毫克/天的甲泼尼龙，在第4 - 21天低于50毫克/天的泼尼松，在第22 - 30天低于30毫克/天，在1个月至1年之间低于20毫克/天。
