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聚合物浓度对微流控纳米沉淀法制备的PHPMAA-PLA接枝共聚物纳米颗粒形态的影响。

Effect of polymer concentration on the morphology of the PHPMAA--PLA graft copolymer nanoparticles produced by microfluidics nanoprecipitation.

作者信息

Petrova Svetlana Lukáš, Pavlova Ewa, Pokorný Václav, Sincari Vladimir

机构信息

Institute of Macromolecular Chemistry v.v.i., Academy of Sciences of the Czech Republic Heyrovsky Sq. 2 162 06 Prague 6 Czech Republic

出版信息

Nanoscale Adv. 2024 Mar 11;6(8):1992-1996. doi: 10.1039/d3na01038d. eCollection 2024 Apr 16.

Abstract

Successful generation of micelles, vesicles, and/or worms with controllable sizes was achieved through the self-assembly process of the poly[-(2-hydroxypropyl)]methacrylamide--polylactide (PHPMAA--PLA) graft copolymer within a microfluidic channel. A product diagram was created to illustrate various morphologies associated with different polymer concentrations, all while maintaining a constant flow velocity ratio between water and the polymer solution.

摘要

通过聚[-(2-羟丙基)]甲基丙烯酰胺-聚丙交酯(PHPMAA-PLA)接枝共聚物在微流控通道内的自组装过程,成功生成了尺寸可控的胶束、囊泡和/或蠕虫状结构。绘制了一个产物示意图,以说明与不同聚合物浓度相关的各种形态,同时保持水和聚合物溶液之间恒定的流速比。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ff6/11019477/ec98e7fb9b8b/d3na01038d-f1.jpg

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