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ESAT-6 在结核病免疫病理学中的作用。

The role of ESAT-6 in tuberculosis immunopathology.

机构信息

Curso de Medicina, Universidade Salvador, Salvador, Brazil.

Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil.

出版信息

Front Immunol. 2024 Apr 3;15:1383098. doi: 10.3389/fimmu.2024.1383098. eCollection 2024.

DOI:10.3389/fimmu.2024.1383098
PMID:38633252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11021698/
Abstract

Despite major global efforts to eliminate tuberculosis, which is caused by (Mtb), this disease remains as a major plague of humanity. Several factors associated with the host and Mtb interaction favor the infection establishment and/or determine disease progression. The Early Secreted Antigenic Target 6 kDa (ESAT-6) is one of the most important and well-studied mycobacterial virulence factors. This molecule has been described to play an important role in the development of tuberculosis-associated pathology by subverting crucial components of the host immune responses. This review highlights the main effector mechanisms by which ESAT-6 modulates the immune system, directly impacting cell fate and disease progression.

摘要

尽管全球在消除结核病（由 Mtb 引起）方面做出了重大努力，但这种疾病仍然是人类的主要瘟疫。宿主与 Mtb 相互作用的几个因素有利于感染的建立和/或决定疾病的进展。早期分泌的抗原靶标 6 kDa（ESAT-6）是最重要和研究最多的分枝杆菌毒力因子之一。该分子通过颠覆宿主免疫反应的关键成分，被描述为在与结核病相关的病理发展中发挥重要作用。本综述强调了 ESAT-6 调节免疫系统的主要效应机制，直接影响细胞命运和疾病进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feb0/11021698/e69a0880f2ee/fimmu-15-1383098-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feb0/11021698/7850b7662145/fimmu-15-1383098-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feb0/11021698/e69a0880f2ee/fimmu-15-1383098-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feb0/11021698/7850b7662145/fimmu-15-1383098-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feb0/11021698/e69a0880f2ee/fimmu-15-1383098-g002.jpg

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