Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-based Medical Materials, Wuhan, Hubei, China.
Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Front Immunol. 2024 Apr 3;15:1360955. doi: 10.3389/fimmu.2024.1360955. eCollection 2024.
With a shortage of organs for transplant, the use of marginal donors can be an effective measure to meet the shortfall. Myelodysplastic syndromes (MDS) are considered an absolute contraindication for organ donation because of the high invasive potential. Currently, organ transplantation from donors with a past history of MDS has not been reported. In this paper, we report the successful clinical experience of one liver transplantation and two kidney transplantations, with organs donated by a 39-year-old patient diagnosed with a past history of MDS following intracranial hemorrhage. Four and a half years after transplantation, the three recipients are all doing well. However, it is still not clear to what extent organs donated by patients with a past history of MDS can be safely transplanted. This report provides support for the careful use of marginal donors. With effective treatment and full peer assessment, livers and kidneys from donors with a past history of MDS may be safely transplanted.
由于器官移植供体短缺，使用边缘供体可以是一种有效措施，以满足短缺。骨髓增生异常综合征（MDS）被认为是器官捐献的绝对禁忌，因为其具有较高的侵袭性。目前，尚无报道从有 MDS 病史的供体中进行器官移植。本文报道了一例肝移植和两例肾移植的成功临床经验，供体为一名 39 岁的颅内出血后诊断为 MDS 病史的患者。移植后 4 年半，三名受者均情况良好。然而，目前仍不清楚 MDS 病史患者的器官可以安全移植的程度。本报告为谨慎使用边缘供体提供了支持。通过有效的治疗和充分的同行评估，MDS 病史供者的肝脏和肾脏可以安全移植。
