Zheng Zeyuan, Sun Huimin, Hu Xiaoyan, Xuan Zuodong, Fu Meiling, Bai Yang, Du Yifan, Liu Bin, Sui Xiuyuan, Zheng Jianzhong, Shao Chen
Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Central Laboratory, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Front Med (Lausanne). 2024 Apr 3;11:1287836. doi: 10.3389/fmed.2024.1287836. eCollection 2024.
The sudden outbreak of coronavirus disease 2019 (COVID-19) in early 2020 posed a massive threat to human life and caused an economic upheaval worldwide. Kidney transplant recipients (KTRs) became susceptible to infection during the COVID-19 pandemic owing to their use of immunosuppressants, resulting in increased hospitalization and mortality rates. Although the current epidemic situation is alleviated, the long-term existence of COVID-19 still seriously threatens the life and health of KTRs with low immunity. The Omicron variant, a highly infectious but less-pathogenic strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has raised concerns among transplant physicians regarding managing KTRs diagnosed with this variant. However, currently, there are no clear and unified guidelines for caring for KTRs infected with this variant. Therefore, we aimed to summarize the ongoing research on drugs that can treat Omicron variant infections in KTRs and explore the potential of adjusting immunotherapy strategies to enhance their responsiveness to vaccines. Herein, we discuss the situation of KTRs since the emergence of COVID-19 and focus on various prevention and treatment strategies for KTRs since the Omicron variant outbreak. We hope to assist physicians in managing KTRs in the presence of long-term COVID-19 variants.
2020年初新型冠状病毒肺炎（COVID-19）的突然爆发对人类生命构成了巨大威胁，并在全球范围内引发了经济动荡。肾移植受者（KTRs）在COVID-19大流行期间由于使用免疫抑制剂而容易受到感染，导致住院率和死亡率上升。尽管当前疫情有所缓解，但COVID-19的长期存在仍然严重威胁着免疫力低下的KTRs的生命和健康。奥密克戎变种是严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的一种高传染性但致病性较低的毒株，这引起了移植医生对管理诊断为此变种的KTRs的担忧。然而，目前对于护理感染此变种的KTRs尚无明确统一的指南。因此，我们旨在总结目前关于可治疗KTRs中奥密克戎变种感染的药物的研究，并探索调整免疫治疗策略以增强其对疫苗反应性的潜力。在此，我们讨论自COVID-19出现以来KTRs的情况，并重点关注自奥密克戎变种爆发以来KTRs的各种预防和治疗策略。我们希望协助医生在长期存在COVID-19变种的情况下管理KTRs。
