Dinç Harika Öykü, Balkan İlker İnanç, Budak Beyhan, Demirci Mehmet, Özbey Doğukan, Karaali Rıdvan, Mete Bilgül, Can Günay, Ergin Sevgi, Kocazeybek Bekir, Saltoğlu Neşe
Department of Pharmaceutical Microbiology, Bezmialem Vakıf University School of Pharmacy, İstanbul, Turkey.
Department of Infectious Diseases, İstanbul University-Cerrahpaşa Cerrahpaşa School of Medicine, İstanbul, Turkey.
Infect Dis Clin Microbiol. 2022 Jun 13;4(2):129-132. doi: 10.36519/idcm.2022.115. eCollection 2022 Jun.
We aimed to describe the antibody response against SARS-CoV-2 after inactivated COVID-19 vaccine in elderly individuals. SARS-CoV-2 IgG levels were measured in the blood samples of 126 volunteers over the age of 60. The antibody positivity rate was 42.8% after the first dose and 96.8% after the second dose of the vaccine. The median antibody titers after two vaccine doses were 561.3AU/mL and 43AU/mL, respectively(<0.001). After vaccination, 22.2% of the participants had antibodies equivalent to 1:80 dilutions in plaque reduction neutralization test (PNRT). We believe that the booster dose is needed to continue the protective immune response in especially elderly groups.
我们旨在描述老年个体接种新冠灭活疫苗后针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的抗体反应。对126名60岁以上志愿者的血液样本进行了SARS-CoV-2 IgG水平检测。首剂疫苗接种后抗体阳性率为42.8%，第二剂疫苗接种后为96.8%。两剂疫苗接种后的抗体滴度中位数分别为561.3AU/mL和43AU/mL（<0.001）。接种疫苗后，22.2%的参与者在空斑减少中和试验（PNRT）中的抗体相当于1:80稀释度。我们认为，尤其在老年群体中，需要接种加强针来持续保护性免疫反应。
