Gönenli Mehmet Gökhan, Kayı İlker, Alpay-Kanıtez Nilüfer, Baydaş Tuba, Köse Murat, Nalbantoğlu Emine Ayça, Keskinler Miraç Vural, Akpınar Timur Selçuk, Ergönül Önder
Department of Internal Medicine, Koç University Hospital, İstanbul, Turkey.
Department of Public Health, Koç University Hospital, İstanbul, Turkey.
Infect Dis Clin Microbiol. 2022 Dec 21;4(4):236-243. doi: 10.36519/idcm.2022.111. eCollection 2022 Dec.
Throughout the pandemic, physicians working at the frontlines have embarked on various quests to protect themselves, and many physicians preferred using hydroxychloroquine (HQN) as a prophylactic agent. This study aimed to investigate the reasons leading physicians to use HQN and its effects on them.
This study is cross-sectional with a target population of physicians working in pandemic hospitals in İstanbul, Turkey. We invited participants from seven hospitals via email between May 14 and June 13, 2020. An online questionnaire, including 57 questions, was sent to physicians.
A total of 148 (26%) physicians out of 564 participants had used hydroxychloroquine for prevention. Older physicians and those with a history of exposure to COVID-19 patients without protection used prophylactic HQN more frequently. The use of HQN did not differ statistically in terms of being infected among the exposed physicians (=0.52). Nineteen (13%) physicians using HQN developed side effects related to the drug. Diarrhea and nausea were the most common.
Prophylactic HQN use was more common among physicians older than 40 years and with higher exposure rates to a COVID-19 patient without protection. The physicians working on the front line had the highest rate of infection. HQN was not effective in the prophylaxis of COVID-19 among the exposed physicians.
在整个疫情期间，一线工作的医生们采取了各种措施来保护自己，许多医生更倾向于使用羟氯喹作为预防药物。本研究旨在调查医生使用羟氯喹的原因及其对他们的影响。
本研究为横断面研究，目标人群是在土耳其伊斯坦布尔的疫情医院工作的医生。2020年5月14日至6月13日期间，我们通过电子邮件邀请了七家医院的参与者。向医生发送了一份包含57个问题的在线问卷。
564名参与者中，共有148名（26%）医生使用羟氯喹进行预防。年龄较大的医生以及有未采取防护措施接触新冠患者病史的医生更频繁地使用预防性羟氯喹。在接触过新冠患者的医生中，使用羟氯喹与否在感染方面无统计学差异（=0.52）。19名（13%）使用羟氯喹的医生出现了与该药物相关的副作用。腹泻和恶心最为常见。
40岁以上且未采取防护措施接触新冠患者比例较高的医生中，预防性使用羟氯喹更为普遍。一线工作的医生感染率最高。羟氯喹在接触过新冠患者的医生中对新冠病毒的预防无效。
