Mohammadi Belgheis, Nazari Robati Leila, Tavakol Zeinab, Movahhed Mina
Clinical Research Development Unit, Hajar Hospital Shahrekord University of Medical Sciences Shahrekord Iran.
Department of Medicine, Tehran Branch Islamic Azad University Tehran Iran.
Health Sci Rep. 2024 Apr 17;7(4):e2029. doi: 10.1002/hsr2.2029. eCollection 2024 Apr.
Due to the concern about the side effects of chemical drugs and their ineffectiveness, the use of natural compounds as alternatives or complementary therapies has received increasing attention. The purpose of this study was to investigate the effect of oil on the outcome of missed abortion.
In this double-blind clinical trial, 70 nulliparous pregnant women referred to Hajar Hospital and Imam Ali clinics of Shahrekord and had missed abortion before the 12-week gestational age were selected and randomly divided into two interventions and control groups. The intervention group received 5 g of oil alone daily for up to 3 days and the control group received a placebo. In case of nonresponse, 3 days after the last dose of medication or placebo, 800 μg of misoprostol (vaginal) were used. Data were analyzed by SPSS software. The chi-square test, Fisher's exact test, independent -test and paired -test were used for analytical statistics.
According to the results, 18 cases (51.4%) in the intervention group and seven cases (20%) in the control group showed complete evacuation of uterine contents which had a significant difference ( < 0.05). The frequency of vagina physical examination and type of hemorrhage did not show any significant difference between the two groups before and after the intervention. After the intervention, human chorionic gonadotropin (HCG) was significantly decreased in the intervention group but did not change in the control group ( < 0.05). The frequency of adverse events in the intervention group was three (8.6%) and in the control group was one (2.9%) which had no significant difference.
improves the outcome of missed abortion by reducing HCG and facilitating cervix dilatation and delivery of uterine contents.
由于对化学药物副作用及其无效性的担忧，使用天然化合物作为替代或补充疗法受到越来越多的关注。本研究的目的是调查[具体油类名称]油对稽留流产结局的影响。
在这项双盲临床试验中，选择了70名未生育的孕妇，她们前往设拉子的哈贾尔医院和伊玛目阿里诊所就诊，且在孕12周前发生了稽留流产，并随机分为两个干预组和对照组。干预组每天单独服用5克[具体油类名称]油，持续3天，对照组服用安慰剂。若无效，在最后一剂药物或安慰剂服用3天后，使用800微克米索前列醇（阴道给药）。数据采用SPSS软件进行分析。卡方检验、Fisher精确检验、独立样本t检验和配对样本t检验用于分析统计。
根据结果，干预组18例（51.4%）和对照组7例（20%）显示子宫内容物完全排出，差异有统计学意义（P<0.05）。两组干预前后阴道体格检查频率和出血类型均无显著差异。干预后，干预组人绒毛膜促性腺激素（HCG）显著下降，而对照组无变化（P<0.05）。干预组不良事件发生率为3例（8.6%），对照组为1例（2.9%），差异无统计学意义。
[具体油类名称]油通过降低HCG、促进宫颈扩张和排出子宫内容物来改善稽留流产的结局。
