Yaragorla Srinivasarao, Khan Tabassum, Chakroborty Sayonika
School of Chemistry, University of Hyderabad, 500046, Telangana, India.
Org Biomol Chem. 2024 May 8;22(18):3622-3629. doi: 10.1039/d4ob00421c.
We report here a simple and atom economic cycloisomerization reaction of indole-tethered alkynols for constructing diverse carbazoles using Cu(OTf)/HFIP as the excellent promoter system. The reaction proceeds through a one-pot, domino process of spiro cyclization and 1,2-migration followed by aromatization to deliver carbazoles.
我们在此报道一种简单且原子经济的吲哚连接炔醇环异构化反应，该反应以Cu(OTf)/HFIP作为优良的促进剂体系来构建多种咔唑。该反应通过一锅法、螺环化和1,2-迁移的多米诺过程，随后进行芳构化以生成咔唑。
