Department of Surgery, Memorial Healthcare System, Hollywood, FL, USA.
Nova Southeastern College of Allopathic Medicine, Fort Lauderdale, FL, USA.
Am Surg. 2024 Sep;90(9):2314-2316. doi: 10.1177/00031348241248815. Epub 2024 Apr 18.
Currently, there is no universally accepted, standardized protocol for pre-operative antibiotic administration in the setting of appendectomy for complicated appendicitis among pediatric patients. Strategies to mitigate surgical site infections (SSIs) must be balanced with optimal antibiotic use and exposure. We conducted a retrospective chart review to compare outcomes between patients treated pre-operatively with a single pre-operative dose of antibiotics with those who received additional antibiotics prior to laparoscopic appendectomy for complicated appendicitis between 2020 and 2022. Of 124 pediatric patients, 18% received an additional dose of pre-operative antibiotics after initial treatment dose. Surgical site infection rates between the two groups were not statistically significant (-value = .352), thereby suggesting that redosing antibiotics closer to the time of incision may not impact SSI rates. Additional studies are necessary to make clinical recommendations.
目前，在小儿复杂性阑尾炎阑尾切除术前应用抗生素方面，尚无被普遍接受的标准化方案。减轻手术部位感染（SSI）的策略必须与最佳抗生素使用和暴露相平衡。我们进行了一项回顾性图表审查，比较了 2020 年至 2022 年期间，在接受腹腔镜阑尾切除术治疗复杂性阑尾炎的患者中，术前单次使用抗生素治疗的患者与术前接受额外抗生素治疗的患者的结局。在 124 名儿科患者中，18%的患者在初始治疗剂量后接受了额外的术前抗生素剂量。两组的手术部位感染率无统计学意义（-值=.352），这表明更接近切口时间的抗生素重剂量给药可能不会影响 SSI 率。需要进一步的研究来提出临床建议。
