Ellis L C, James L F, McMullen R W, Panter K E
Am J Vet Res. 1985 Sep;46(9):1903-7.
Feeding 300 or 400 g of dried spotted locoweed, Astragalus lentiginosus per day to 11 pregnant Columbia ewes from the 20th to the 50th days of their gestations resulted in dead and edematous fetuses. Aspartate aminotransferase values were increased, whereas serum progesterone values were significantly diminished (P less than 0.05) in a dose-dependent manner by locoweed ingestion. Cotyledonary 6-keto-prostaglandin (PG)F1 alpha (400 g/day only) and PGF2 alpha (300 and 400 g/day) values were significantly increased (P less than 0.05), whereas PGE values were not affected by the treatment. Alterations in PG values in these sheep may be a mechanism for altering corpus luteum function and inducing fetal death, which would ultimately result in abortion.
从妊娠第20天到第50天，每天给11只怀孕的哥伦比亚母羊喂食300克或400克斑点疯草（Astragalus lentiginosus）干品，导致胎儿死亡且出现水肿。摄入疯草后，天冬氨酸转氨酶值升高，而血清孕酮值呈剂量依赖性显著降低（P小于0.05）。子叶中6-酮-前列腺素（PG）F1α（仅400克/天）和PGF2α（300克/天和400克/天）值显著升高（P小于0.05），而PGE值不受该处理影响。这些绵羊PG值的变化可能是改变黄体功能和导致胎儿死亡的一种机制，最终会导致流产。
