Department of Microbiology and Immunology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Department of Physician Assistant Studies, College of Health and Allied Sciences School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
PLoS One. 2024 Apr 18;19(4):e0301295. doi: 10.1371/journal.pone.0301295. eCollection 2024.
Head and neck tumors (HNT) are tumors of the paranasal sinuses, the salivary glands and the upper aerodigestive tract. RIN1 is a Ras effector protein regulating epithelial cell properties and has been implicated in a number of cancers.
The aim of this study was to investigate the expression of RIN1 in head and neck tumors. RIN1 expression was assessed using quantitative real-time PCR (qRT-PCR) and immunohistochemical staining on archival head and neck tissue samples between 2014 and 2020.
RIN1 expression was low in tissue samples as compared with the normal head and neck tissues. High and low RIN1 levels were compared with ages ≤40, >40 in the head and neck tumors of p-value 0.02. There was a significant difference with p-values of 0.001 when poor and well-moderate malignant tumors were compared.
Our data suggests that RIN1may play an important role in head and neck tumor progression and that its expression may provide baseline data to facilitate identification of new molecular targeted therapeutics.
头颈部肿瘤（HNT）是发生于副鼻窦、唾液腺和上呼吸道的肿瘤。RIN1 是一种 Ras 效应蛋白，调节上皮细胞特性，与多种癌症有关。
本研究旨在研究 RIN1 在头颈部肿瘤中的表达。在 2014 年至 2020 年间，我们使用定量实时 PCR（qRT-PCR）和免疫组织化学染色对头颈部组织样本进行 RIN1 表达评估。
与正常头颈部组织相比，组织样本中 RIN1 的表达较低。高 RIN1 水平和低 RIN1 水平与头颈部肿瘤患者年龄≤40 岁和＞40 岁相比，p 值为 0.02。当比较低分化和中高分化恶性肿瘤时，p 值为 0.001，差异有统计学意义。
我们的数据表明，RIN1 可能在头颈部肿瘤进展中发挥重要作用，其表达可能为识别新的分子靶向治疗药物提供基线数据。
