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巨核细胞中赖氨酸氧化酶的缺失以性别依赖的方式影响骨骼特性。

Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner.

机构信息

Department of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.

Department of Internal Medicine, University of Crete, School of Medicine, Heraklion, Greece.

出版信息

Blood. 2024 Jun 20;143(25):2666-2670. doi: 10.1182/blood.2024024620.

DOI:10.1182/blood.2024024620
PMID:38635757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11196861/
Abstract

Lysyl oxidase (LOX) is a facilitator of extracellular matrix cross-linking. Using newly developed megakaryocyte-specific LOX knockout mice, we show that LOX expressed in these scarce bone marrow cells affects bone volume and collagen architecture in a sex-dependent manner.

摘要

赖氨酰氧化酶（LOX）是细胞外基质交联的促进剂。利用新开发的巨核细胞特异性 LOX 敲除小鼠，我们表明这些在骨髓中稀少表达的细胞中的 LOX 以性别依赖的方式影响骨量和胶原结构。

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Nat Commun. 2023 Mar 17;14(1):1497. doi: 10.1038/s41467-023-37175-8.
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Front Oncol. 2022 Jul 8;12:929498. doi: 10.3389/fonc.2022.929498. eCollection 2022.
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