Université Paris Cité, Sorbonne Paris-Nord, INRAE, INSERM, UMR 1153-CRESS, HERA Team, 1 Parvis Notre-Dame - Pl. Jean-Paul II, 75004 Paris, France.
Université Paris Cité, Sorbonne Paris-Nord, INRAE, INSERM, UMR 1153-CRESS, HERA Team, 1 Parvis Notre-Dame - Pl. Jean-Paul II, 75004 Paris, France; Faculté de Pharmacie, 4 avenue de l'observatoire, 75006 Paris, France.
Sci Total Environ. 2024 Jun 20;930:172543. doi: 10.1016/j.scitotenv.2024.172543. Epub 2024 Apr 16.
The relationship between sunlight and allergies in children has received limited attention from researchers. We sought to explore how early exposure to solar radiation is associated with allergic morbidity within the PARIS birth cohort study. Our research dealt with children who attended at least one of two health checkups: at 18 months (n = 2012) and at 8-9 years (n = 1080). Early exposure to solar radiation was assessed using meteorological data (e.g., solar radiation, temperature, and relative humidity). Children with similar meteorological exposure trajectories were grouped by a longitudinal and multidimensional cluster analysis. The association between solar radiation exposure and allergic morbidity (i.e., allergic sensitization at 18 months and 8-9 years; current asthma, rhinitis, and eczema at 8-9 years) was quantified by multivariable logistic regression models adjusted for potential confounders. The effect modification of maternal vitamin D supplementation during pregnancy was tested. Four meteorological exposure trajectories were found. The trajectory with the highest exposure to early solar radiation had a reduced risk of sensitization at 8-9 years compared to the trajectory with the lowest exposure (p = 0.06). The association was statistically significant in the vitamin D supplementation group. Solar radiation during prenatal and postnatal periods was significantly associated with a lower risk of sensitization at 8-9 years (for one interquartile range (IQR) increase, adjusted odds ratio (aOR): 0.47; 95 % confidence interval (CI): 0.25-0.87 and 0.84; 0.7-1.00, respectively). Increased prenatal exposure to solar radiation was significantly associated with a lower risk of asthma at 8-9 years (for one IQR increase, aOR: 0.32; 95 % CI: 0.1-0.96). Early sunlight exposure may reduce the risk of sensitization and asthma in school-aged children, especially in those prenatally exposed to vitamin D. These findings highlight the importance of vitamin D in preventing allergic diseases in children, either through supplementation or sunlight exposure.
儿童期阳光与过敏的关系一直受到研究人员的关注。我们旨在探讨早期暴露于太阳辐射与巴黎出生队列研究中过敏性发病的相关性。我们的研究涉及参加至少一次健康检查的儿童：18 个月时（n=2012）和 8-9 岁时（n=1080）。早期暴露于太阳辐射通过气象数据（例如，太阳辐射、温度和相对湿度）进行评估。采用纵向和多维聚类分析对具有相似气象暴露轨迹的儿童进行分组。采用多变量逻辑回归模型调整潜在混杂因素后，定量评估太阳辐射暴露与过敏发病（即 18 个月和 8-9 岁时的过敏致敏；8-9 岁时的当前哮喘、鼻炎和湿疹）之间的关联。检测了母亲妊娠期间维生素 D 补充的效应修饰作用。发现了 4 种气象暴露轨迹。与最低暴露轨迹相比，暴露于早期太阳辐射最高的轨迹 8-9 岁时致敏的风险降低（p=0.06）。在维生素 D 补充组中，该关联具有统计学意义。妊娠和产后期间的太阳辐射与 8-9 岁时致敏风险降低显著相关（每增加一个四分位距，调整后的优势比（aOR）：0.47；95%置信区间（CI）：0.25-0.87 和 0.84；0.7-1.00）。妊娠期间暴露于太阳辐射增加与 8-9 岁时哮喘风险降低显著相关（每增加一个四分位距，aOR：0.32；95%CI：0.1-0.96）。早期阳光暴露可能会降低学龄儿童过敏和哮喘的风险，尤其是在产前接触维生素 D 的儿童中。这些发现强调了维生素 D 在通过补充或阳光暴露预防儿童过敏疾病中的重要性。
