三重心血管质量指数与左心室肥厚在白人肥胖青少年队列中的表现。
Tri-ponderal mass index and left ventricular hypertrophy in a cohort of caucasian children and adolescents with obesity.
机构信息
Department of Pediatrics, Buzzi Children's Hospital, University of Milan, Milan, Italy.
Centro Cardiologico Monzino IRCCS, Milan, Italy.
出版信息
Ital J Pediatr. 2024 Apr 19;50(1):75. doi: 10.1186/s13052-024-01634-9.
BACKGROUND
Pediatric obesity is a global emerging burden for society; among its health-related consequences there are hypertension (HTN) and left ventricular hypertrophy (LVH). Several anthropometric indices have been investigated for the early identification of cardiovascular risk in children. The aim of the present study was to assess whether tri-ponderal mass index (TMI) was associated with LVH in a cohort of Caucasian children and adolescents with obesity.
METHODS
In this observational study, 63 children and adolescents with obesity aged 7-to-16 years were enrolled. During outpatient visits, adiposity, and cardio-metabolic indices (BMI z-score, WHR, TMI, ABSI) were collected. All subjects underwent a 24-hour ambulatory blood pressure monitoring (ABPM) and transthoracic echocardiography.
RESULTS
Children and adolescents with obesity with LVH had significantly higher BMI z-score (p = 0.009), WHR (p = 0.006) and TMI (p = 0.026) compared to children without LVH. WC and WHR were the only indices significantly associated with left ventricular mass index (LVMI).
CONCLUSION
Left ventricular remodeling is associated with the cardio-metabolic risk markers WC and WHR, but not with the adiposity index TMI among children with obesity.
背景
儿科肥胖是全球社会面临的新兴负担；其与健康相关的后果包括高血压（HTN）和左心室肥厚（LVH）。已经研究了几种人体测量指数，以早期识别儿童的心血管风险。本研究旨在评估三重点质量指数（TMI）是否与肥胖的白种人儿童和青少年中的 LVH 相关。
方法
在这项观察性研究中，纳入了 63 名 7 至 16 岁的肥胖儿童和青少年。在门诊就诊期间，收集了肥胖和心脏代谢指数（BMI z 评分、WHR、TMI、ABSI）。所有受试者均接受 24 小时动态血压监测（ABPM）和经胸超声心动图检查。
结果
与无 LVH 的儿童相比，患有 LVH 的肥胖儿童和青少年的 BMI z 评分（p=0.009）、WHR（p=0.006）和 TMI（p=0.026）显著更高。WC 和 WHR 是唯一与左心室质量指数（LVMI）显著相关的指数。
结论
在肥胖儿童中，左心室重构与心脏代谢风险标志物 WC 和 WHR 相关，但与肥胖指数 TMI 无关。
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