J Emerg Nurs. 2024 Jul;50(4):496-498. doi: 10.1016/j.jen.2024.03.003. Epub 2024 Apr 18.
Cefoperazone (CPZ) is an antibiotic widely used for moderate to severe infections, especially in countries where resources are difficult to access. This case report aimed to draw attention to coagulopathy, a potential side effect of CPZ. This side effect can cause high mortality and morbidity in patients. In the mechanism of CPZ causing coagulopathy, it is reported that effects such as binding to vitamin K, disrupting vitamin K metabolism, and preventing platelet aggregation are responsible. In this presentation, a case who came to the emergency department with the complaint of hematuria caused by coagulopathy after the use of CPZ-containing antibiotics (CPZ + sulbactam) is presented.
头孢哌酮（CPZ）是一种广泛用于治疗中度至重度感染的抗生素，尤其在资源难以获取的国家。本病例报告旨在引起人们对 CPZ 可能引起的凝血功能障碍这一潜在副作用的关注。这种副作用可能导致使用 CPZ 类抗生素（CPZ+舒巴坦）的患者死亡率和发病率升高。在 CPZ 引起凝血功能障碍的机制中，据报道，其与维生素 K 结合、干扰维生素 K 代谢以及抑制血小板聚集等作用有关。本报告介绍了 1 例因使用 CPZ 类抗生素（CPZ+舒巴坦）而出现凝血功能障碍导致血尿的患者来急诊科就诊的病例。
