揭示 DHX9 的奥秘：紫外线诱导的应激颗粒阐明了子细胞弹性的保护机制。

Shining light on DHX9: UV-induced stress granules illuminate protective mechanisms for daughter cell resilience.

机构信息

Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80309, USA; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80309, USA.

Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80309, USA.

出版信息

Mol Cell. 2024 Apr 18;84(8):1403-1405. doi: 10.1016/j.molcel.2024.03.027.

DOI:10.1016/j.molcel.2024.03.027

PMID:38640893

Abstract

In a recent article in Cell, Zhou et al. investigate the origins, composition, and biological consequences of UV-induced stress granules. They find that UV-induced stress granules are triggered by the formation of RNA-protein crosslinks, uniquely contain DHX9 as a marker, form during mitosis independently of translation repression, and are enriched in intron-containing RNAs and splicing factors. Moreover, UV-induced granules contain double-stranded RNA (dsRNA) and trigger a dsRNA response. This work identifies a mechanism for resolving UV-damaged RNA and broadens the types of cytosolic "stress granules" that form.

摘要

在最近发表在《细胞》杂志上的一篇文章中，Zhou 等人研究了 UV 诱导的应激颗粒的起源、组成和生物学后果。他们发现，UV 诱导的应激颗粒是由 RNA-蛋白质交联的形成触发的，独特地包含 DHX9 作为标志物，在有丝分裂过程中独立于翻译抑制形成，并且富含内含子 RNA 和剪接因子。此外，UV 诱导的颗粒含有双链 RNA（dsRNA）并引发 dsRNA 反应。这项工作确定了一种解决 UV 损伤 RNA 的机制，并拓宽了形成细胞质“应激颗粒”的类型。