Department of Anesthesia, McMaster University, Hamilton, ON, Canada.
Department of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Br J Anaesth. 2024 May;132(5):1027-1032. doi: 10.1016/j.bja.2024.01.019. Epub 2024 Feb 22.
The conduct and reporting of studies with a noninferiority hypothesis is challenging because of the complexity involved in their design and interpretation. However, studies with a noninferiority design have increased in popularity. A recently published trial reported on the noninferiority of lidocaine infusion to epidural analgesia in major abdominal surgeries. Apart from needing a critical appraisal, this draws attention to improve our understanding of noninferiority study framework and its unique features. Given the increasing focus on using various analgesic adjuncts and multiple approaches to fascial plane blocks to avoid more definitive and standard approaches, it is imperative that particular attention is paid to appropriate execution and reporting of noninferiority studies.
具有非劣效性假设的研究的实施和报告具有挑战性，因为其设计和解释涉及到复杂性。然而，具有非劣效性设计的研究越来越受欢迎。最近发表的一项试验报告了利多卡因输注在大型腹部手术中的非劣效性，与硬膜外镇痛相比。除了需要批判性评价外，这也引起了人们对提高我们对非劣效性研究框架及其独特特征的理解的关注。鉴于越来越关注使用各种镇痛辅助手段和多种筋膜平面阻滞方法来避免更明确和标准的方法，因此必须特别注意非劣效性研究的正确执行和报告。
