School of Biological and Health Systems Engineering, Arizona State University, 501 E. Tyler Mall, MC 9709, Tempe, AZ, 85287, USA.
Department of Neurology and Department of Physical Medicine and Rehabilitation, Grossman School of Medicine, New York University, New York, NY, USA.
Sci Rep. 2024 Apr 20;14(1):9094. doi: 10.1038/s41598-024-59927-2.
Transcranial direct current stimulation (tDCS) can be used to non-invasively augment cognitive training. However, the benefits of tDCS may be due in part to placebo effects, which have not been well-characterized. The purpose of this study was to determine whether tDCS can have a measurable placebo effect on cognitive training and to identify potential sources of this effect. Eighty-three right-handed adults were randomly assigned to one of three groups: control (no exposure to tDCS), sham tDCS, or active tDCS. The sham and active tDCS groups were double-blinded. Each group performed 20 min of an adapted Corsi Block Tapping Task (CBTT), a visuospatial working memory task. Anodal or sham tDCS was applied during CBTT training in a right parietal-left supraorbital montage. After training, active and sham tDCS groups were surveyed on expectations about tDCS efficacy. Linear mixed effects models showed that the tDCS groups (active and sham combined) improved more on the CBTT with training than the control group, suggesting a placebo effect of tDCS. Participants' tDCS expectations were significantly related to the placebo effect, as was the belief of receiving active stimulation. This placebo effect shows that the benefits of tDCS on cognitive training can occur even in absence of active stimulation. Future tDCS studies should consider how treatment expectations may be a source of the placebo effect in tDCS research, and identify ways to potentially leverage them to maximize treatment benefit.
经颅直流电刺激(tDCS)可用于非侵入性地增强认知训练。然而,tDCS 的益处可能部分归因于安慰剂效应,而这种效应尚未得到很好的描述。本研究的目的是确定 tDCS 是否可以对认知训练产生可衡量的安慰剂效应,并确定这种效应的潜在来源。83 名右利手成年人被随机分配到三组之一:对照组(不接受 tDCS 暴露)、假 tDCS 组或真 tDCS 组。假 tDCS 和真 tDCS 组均采用双盲设计。每组进行 20 分钟的改良 Corsi 块打点任务(CBTT),一种视觉空间工作记忆任务。在 CBTT 训练期间,采用右顶叶-左眶上的电极放置方式给予阳极或假 tDCS。训练后,真 tDCS 和假 tDCS 组被调查对 tDCS 疗效的期望。线性混合效应模型显示,与对照组相比,tDCS 组(真 tDCS 和假 tDCS 组的总和)在 CBTT 训练中改善更多,提示 tDCS 具有安慰剂效应。参与者对 tDCS 的期望与安慰剂效应显著相关,而接受真实刺激的信念也与安慰剂效应相关。这种安慰剂效应表明,即使没有真实刺激,tDCS 对认知训练的益处也可以产生。未来的 tDCS 研究应考虑治疗期望如何成为 tDCS 研究中安慰剂效应的一个来源,并确定潜在的利用方法来最大限度地提高治疗效果。