Erasmus MC, Division Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, PO Box 2040, 3000 CA Rotterdam, the Netherlands.
Erasmus MC, Division Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, PO Box 2040, 3000 CA Rotterdam, the Netherlands.
Maturitas. 2024 Jun;184:107994. doi: 10.1016/j.maturitas.2024.107994. Epub 2024 Apr 17.
Premature ovarian insufficiency (POI) is a rare condition characterized by loss of ovarian function before the age of 40. POI seems associated with mood disorders and sexual dysfunction. However, there is a lack of high-quality evidence relating to the impact of POI on sexual function. Therefore, we conducted a systematic review and meta-analysis to evaluate sexual function in women with POI compared to women without the condition. The following online databases were systematically searched up to January 2023: EMBASE, Medline (Ovid), Web of Science, Cochrane, PsychInfo, and Google Scholar. Random effects models were used for analyses, with data reported as Hedges' g and 95 % confidence interval, and the risk of heterogeneity was evaluated. The protocol of this study was registered with PROSPERO (CRD42023437203). A total of 10 studies were included in the systematic review and 5 studies involving 352 women with POI were included in the meta-analysis. Eight of the ten studies concluded that women with POI have reduced sexual function. An overall medium Hedges' g effect size of -0.72 was found (ranging between -0.20 and -1.29) in favor of control women, with moderate heterogeneity (I = 64 %). Stratified studies of women on systemic hormone replacement therapy (HRT) showed an even higher Hedges' g effect size, of -0.82 (95 % CI -1.18, -0.47). In conclusion, sexual function in women with POI is reduced compared with control women. Sexual function should be discussed with women with POI and they should be offered psychosexual counseling.
卵巢早衰（POI）是一种罕见的病症，其特征是在 40 岁之前卵巢功能丧失。POI 似乎与情绪障碍和性功能障碍有关。然而，目前缺乏与 POI 对性功能影响相关的高质量证据。因此，我们进行了一项系统评价和荟萃分析，以评估 POI 女性与无 POI 女性的性功能。截至 2023 年 1 月，我们系统地检索了以下在线数据库：EMBASE、Medline（Ovid）、Web of Science、Cochrane、PsychInfo 和 Google Scholar。采用随机效应模型进行分析，数据以 Hedges'g 和 95%置信区间报告，并评估异质性风险。本研究的方案已在 PROSPERO（CRD42023437203）上注册。系统评价共纳入 10 项研究，荟萃分析纳入了 5 项涉及 352 名 POI 女性的研究。10 项研究中有 8 项结论认为 POI 女性的性功能下降。总体而言，倾向于对照组的中等 Hedges'g 效应大小为-0.72（范围为-0.20 至-1.29），存在中度异质性（I=64%）。对接受全身激素替代疗法（HRT）的女性进行的分层研究显示，Hedges'g 效应大小甚至更高，为-0.82（95%CI -1.18，-0.47）。总之，POI 女性的性功能较对照组女性下降。应与 POI 女性讨论性功能问题，并为她们提供性心理咨询。
