Bourgeois Stephanie, Coenen Sophie, Degroote Laure, Willems Lien, Van Mulders Annelore, Pierreux Julie, Heremans Yves, De Leu Nico, Staels Willem
Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium.
Genetics, Reproduction, and Development (GRAD), Beta Cell Neogenesis (BENE) Research Unit, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium; Endocrinology, Universiteit Ziekenhuis Brussel (UZ Brussel), 1090 Brussels, Belgium; Endocrinology, ASZ Aalst, 9300 Aalst, Belgium.
Trends Endocrinol Metab. 2024 Nov;35(11):951-966. doi: 10.1016/j.tem.2024.03.006. Epub 2024 Apr 21.
The pandemic scale of diabetes mellitus is alarming, its complications remain devastating, and current treatments still pose a major burden on those affected and on the healthcare system as a whole. As the disease emanates from the destruction or dysfunction of insulin-producing pancreatic β-cells, a real cure requires their restoration and protection. An attractive strategy is to regenerate β-cells directly within the pancreas; however, while several approaches for β-cell regeneration have been proposed in the past, clinical translation has proven challenging. This review scrutinizes recent findings in β-cell regeneration and discusses their potential clinical implementation. Hereby, we aim to delineate a path for innovative, targeted therapies to help shift from 'caring for' to 'curing' diabetes.
糖尿病的流行规模令人担忧，其并发症仍然具有毁灭性，目前的治疗方法仍然给患者个体以及整个医疗系统带来沉重负担。由于该疾病源于产生胰岛素的胰腺β细胞的破坏或功能障碍，真正的治愈方法需要恢复和保护这些细胞。一种有吸引力的策略是在胰腺内直接再生β细胞；然而，尽管过去已经提出了几种β细胞再生方法，但临床转化已证明具有挑战性。本综述仔细研究了β细胞再生的最新发现，并讨论了它们在临床上的潜在应用。在此，我们旨在勾勒出一条创新的靶向治疗路径，以帮助从“治疗”糖尿病转向“治愈”糖尿病。
