Kang L M, Mi R, Cui X D, Fu J, Wang W P, Li L, Li T G, Wang X Y, Xiao F, Hou X L
Department of Neonatal Medicine, Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.
Central Lab, Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing 100020, China.
Zhonghua Yi Xue Za Zhi. 2024 Apr 23;104(16):1422-1425. doi: 10.3760/cma.j.cn112137-20231107-01030.
Demographic data and clinical data were collected retrospectively from patients with pertussis at the Children's Hospital Affiliated to the Capital Institute of Pediatrics between March 2011 and February 2023. Among the 270 hospitalized patients, 151 cases were male and 119 were female. The youngest age of admission was 10 days and the eldest age of admission was 11 years. The 270 hospitalized patients were divided into two groups according to onset age: <3 months (=143) and≥3 months (=127). For those in the <3-month-old group, the incidence of severe pneumonia and severe pertussis were 21.0% and 38.5%, respectively, both were significantly higher than those in≥3-month-old group (7.9% and 11.0%, both <0.05). For those in the <3-month-old group, paroxysmal spasmodic cough, post-tussive vomiting, paroxysmal cyanosis, apnea, and decreased heart rate after coughing were 86.7%, 25.2%, 38.5%, 7.0% and 16.8%, respectively, all were significantly higher than those in ≥3-month-old group (76.4%, 10.2%, 15.7%, 1.6% and 1.6%, all <0.05). For those in the<3-month-old group, the incidence of hypoxemia, respiratory failure, were 36.4%, 16.8%, respectively, and both were significantly higher than those in≥3-month-old group (10.2%, 7.1%, <0.05). It indicated that among the infants under 3 months, the incidence of vomiting after coughing, paroxysmal cyanosis, apnea, hypoxemia, respiratory failure, decreased heart rate after coughing and severe pneumonia were significantly higher than those above 3 months. Infants under 3 months were prone to severe pertussis.
回顾性收集2011年3月至2023年2月期间首都儿科研究所附属儿童医院百日咳患者的人口统计学数据和临床数据。270例住院患者中，男性151例，女性119例。最小入院年龄为10天，最大入院年龄为11岁。270例住院患者按发病年龄分为两组：<3个月（=143例）和≥3个月（=127例）。<3月龄组重症肺炎和重症百日咳的发生率分别为21.0%和38.5%，均显著高于≥3月龄组（7.9%和11.0%，均<0.05）。<3月龄组阵发性痉挛性咳嗽、咳嗽后呕吐、阵发性发绀、呼吸暂停及咳嗽后心率下降的发生率分别为86.7%、25.2%、38.5%、7.0%和16.8%，均显著高于≥3月龄组（76.4%、10.2%、15.7%、1.6%和1.6%，均<0.05）。<3月龄组低氧血症、呼吸衰竭的发生率分别为36.4%、16.8%，均显著高于≥3月龄组（10.2%、7.1%，<0.05）。提示3个月以下婴儿咳嗽后呕吐、阵发性发绀、呼吸暂停、低氧血症、呼吸衰竭、咳嗽后心率下降及重症肺炎的发生率显著高于3个月以上婴儿。3个月以下婴儿易患重症百日咳。
