Hu Ya-Hong, Yao Kai-Hu
National Center for Children's Medicine/Beijing Children's Hospital, Capital Medical University/Laboratory of Infection and Microbiology, Beijing Pediatric Research Institute/National Clinical Research Center for Respiratory Diseases/National Clinical Surveillance Center for Pediatric Infectious Diseases and Allergic Disorders/National Key Discipline of Pediatrics/Key Laboratory of Major Diseases in Children, Ministry of Education/Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Beijing 100045, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2025 Jul 15;27(7):786-791. doi: 10.7499/j.issn.1008-8830.2501077.
In recent years, the incidence rate of pertussis in China has been steadily increasing, presenting an increasingly severe challenge for disease prevention and control. To strengthen the immune barrier in the population and effectively curb the spread of pertussis, National Disease Control and Prevention Administration of China and other relevant authorities optimized the immunization procedure for diphtheria-tetanus-pertussis vaccine, with the new procedure implemented in 2025. This adjustment includes three key measures: advancing the initial dose of the vaccine from 3 months to 2 months of age, extending the interval between primary immunization doses from 1 month to 2 months, and adding an extra dose of acellular diphtheria-tetanus-pertussis vaccine at 6 years of age. This article discusses potential changes in the epidemiology and clinical manifestations of pertussis following such adjustments for immunization procedure, and awareness of these changes will facilitate the accurate identification of pertussis cases, which is crucial for evaluating the impact of these adjustments and further optimizing immunization strategies.
近年来，我国百日咳发病率呈稳步上升趋势，给疾病防控带来了日益严峻的挑战。为强化人群免疫屏障，有效遏制百日咳传播，国家疾病预防控制局等相关部门优化了白喉-破伤风-百日咳疫苗的免疫程序，并于2025年实施新程序。此次调整包括三项关键措施：将疫苗首剂接种月龄从3个月提前至2个月，将基础免疫剂次间隔从1个月延长至2个月，以及在6岁时增加一剂无细胞白喉-破伤风-百日咳疫苗。本文探讨了免疫程序调整后百日咳流行病学及临床表现可能发生的变化，认识这些变化将有助于准确识别百日咳病例，这对于评估这些调整的影响及进一步优化免疫策略至关重要。
