Perennec Tanguy, Rogé Maximilien, Hetet Jean-François, Colls Philippe, Guimas Valentine, Rio Emmanuel, Vaugier Loïg, Supiot Stéphane
Department of Radiation Oncology, Institut de Cancérologie de L'Ouest, Bd Professeur Jacques Monod, 44800, Saint-Herblain, France.
Department of Radiation Oncology, Centre Henri Becquerel, 1 Rue d'Amiens, 76000, Rouen, France.
Sci Rep. 2024 Apr 21;14(1):9148. doi: 10.1038/s41598-024-59406-8.
Cryotherapy is an ablative therapy that can be used to treat localized prostate cancer. In case of recurrence, treatment options are not well-defined, and their outcomes are unknown. We therefore collected all patients treated with radiotherapy after cryotherapy for prostate cancer recurrence in Nantes (France) between 2012 and 2019. We identified ten patients. After a median follow-up of 5 years, two patients presented late grade 3 toxicities; one patient presented a grade 3 rectal hemorrhage, and one had a grade 3 hematuria. Two patients relapsed at 61 and 62 months, and three patients died of other causes. Radiotherapy to treat local prostate cancer recurrence after cryotherapy seems feasible and effective in local control. These results do not allow us to recommend this technique in current practice but are encouraging for the conduct of prospective trials.
冷冻疗法是一种可用于治疗局限性前列腺癌的消融疗法。在复发的情况下，治疗方案尚不明确，其结果也未知。因此，我们收集了2012年至2019年期间在法国南特接受冷冻治疗后因前列腺癌复发而接受放射治疗的所有患者。我们确定了10名患者。中位随访5年后，2名患者出现晚期3级毒性反应；1名患者出现3级直肠出血，1名患者出现3级血尿。2名患者分别在61个月和62个月时复发，3名患者死于其他原因。冷冻治疗后放射治疗局部前列腺癌复发似乎在局部控制方面可行且有效。这些结果目前不允许我们在临床实践中推荐该技术，但对开展前瞻性试验具有鼓舞作用。
