Marri Laxman Reddy Institute of Pharmacy, Hyderabad, India.
College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, India.
Curr Gene Ther. 2024;25(1):22-33. doi: 10.2174/0115665232262213240329034826.
L-arginine is a semi-essential amino acid that plays a critical role in various physiological processes, such as protein synthesis, wound healing, immune function, and cardiovascular regulation. The use of L-arginine in pregnancy has been an emerging topic in the field of pharmacogenomics. L-arginine, an amino acid, plays a crucial role in the production of nitric oxide, which is necessary for proper placental development and fetal growth. Studies have shown that L-arginine supplementation during pregnancy can have positive effects on fetal growth, maternal blood pressure, and the prevention of preeclampsia. This emerging pharmacogenomic approach involves using genetic information to personalize L-arginine dosages for pregnant women based on their specific genetic makeup. By doing so, it may be possible to optimize the benefits of L-arginine supplementation during pregnancy and improve pregnancy outcomes. This paper emphasizes the potential applications of L-arginine in pregnancy and the use of pharmacogenomic approaches to enhance its effectiveness. Nonetheless, the emerging pharmacogenomic approach to the application of L-arginine offers exciting prospects for the development of novel therapies for a wide range of diseases.
精氨酸是一种半必需氨基酸，在多种生理过程中发挥着关键作用，如蛋白质合成、伤口愈合、免疫功能和心血管调节。精氨酸在妊娠中的应用是药物基因组学领域的一个新兴课题。精氨酸是一种氨基酸，在一氧化氮的产生中起着关键作用，而一氧化氮是胎盘正常发育和胎儿生长所必需的。研究表明，妊娠期间补充精氨酸对胎儿生长、产妇血压和预防子痫前期有积极影响。这种新兴的药物基因组学方法涉及使用遗传信息根据孕妇的特定基因构成来个性化精氨酸剂量。这样，就有可能优化妊娠期间精氨酸补充的益处并改善妊娠结局。本文强调了精氨酸在妊娠中的潜在应用以及使用药物基因组学方法来增强其效果。然而，应用精氨酸的新兴药物基因组学方法为治疗广泛的疾病提供了新疗法的令人兴奋的前景。
