CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China.
ACS Biomater Sci Eng. 2024 May 13;10(5):2841-2862. doi: 10.1021/acsbiomaterials.4c00491. Epub 2024 Apr 22.
Cancer is a severe threat to humans, as it is the second leading cause of death after cardiovascular diseases and still poses the biggest challenge in the world of medicine. Due to its higher mortality rates and resistance, it requires a more focused and productive approach to provide the solution for it. Many therapies promising to deliver favorable results, such as chemotherapy and radiotherapy, have come up with more negatives than positives. Therefore, a new class of medicinal solutions and a more targeted approach is of the essence. This review highlights the alluring properties, configurations, and self-assembly of peptide molecules which benefit the traditional approach toward cancer therapy while sparing the healthy cells in the process. As targeted drug delivery systems, self-assembled peptides offer a wide spectrum of conjugation, biocompatibility, degradability-controlled responsiveness, and biomedical applications, including cancer treatment and cancer imaging.
癌症是人类的严重威胁,它是心血管疾病之后的第二大死亡原因,仍然是医学领域的最大挑战。由于其死亡率较高且具有抗药性,因此需要更集中和更有成效的方法来提供解决方案。许多有希望带来有利结果的疗法,如化疗和放疗,带来的负面影响多于正面影响。因此,新型药物解决方案和更有针对性的方法是必不可少的。这篇综述强调了肽分子的诱人特性、结构和自组装,这些特性有益于传统的癌症治疗方法,同时在治疗过程中保护健康细胞。作为靶向药物递送系统,自组装肽提供了广泛的缀合、生物相容性、可控降解响应性和生物医学应用,包括癌症治疗和癌症成像。